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Peptide Database

265 therapeutic peptides with research summaries, clinical findings, and regulatory status.

Showing 1–36 of 86 with status FDA ApprovedClear filters
RecoveryFDA Approved

Pentosan Polysulfate (Elmiron)

A semi-synthetic sulfated polysaccharide derived from beechwood hemicellulose with structural similarities to glycosaminoglycans. Pentosan…

Oral
MetabolicFDA Approved

Semaglutide (Ozempic/Wegovy)

A glucagon-like peptide-1 receptor agonist (GLP-1 RA) with 94% amino acid homology to native GLP-1. Semaglutide enhances glucose-dependent insulin…

Subcutaneous injection (weekly), Oral (daily - Rybelsus)
MetabolicFDA Approved

Tirzepatide (Mounjaro/Zepbound)

A first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. Tirzepatide activates both incretin pathways…

Subcutaneous injection (weekly)
MetabolicFDA Approved

Liraglutide (Saxenda/Victoza)

A GLP-1 receptor agonist with 97% homology to native GLP-1, modified with a fatty acid side chain (C-16 palmitoyl) enabling albumin binding and a…

Subcutaneous injection (daily)
MetabolicFDA Approved

Exenatide (Byetta/Bydureon)

A synthetic version of exendin-4, a 39-amino acid peptide originally isolated from the saliva of the Gila monster lizard (Heloderma suspectum).…

Subcutaneous injection (twice daily or weekly extended-release)
MetabolicFDA Approved

Glucagon

A 29-amino acid peptide hormone produced by alpha cells of the pancreatic islets of Langerhans. Glucagon acts primarily on hepatocytes via the…

Subcutaneous injection, Intramuscular injection, Intranasal
MetabolicFDA Approved

Pramlintide (Symlin)

A synthetic analog of amylin (islet amyloid polypeptide), a 37-amino acid peptide hormone co-secreted with insulin from pancreatic beta cells.…

Subcutaneous injection (before meals)
MetabolicFDA Approved

Dulaglutide (Trulicity)

A long-acting GLP-1 receptor agonist consisting of a GLP-1 analog covalently linked to a modified human IgG4 Fc fragment via a peptide linker. This…

Subcutaneous injection (weekly)
MetabolicFDA Approved

Lixisenatide (Adlyxin)

A selective GLP-1 receptor agonist derived from exendin-4 with a modified C-terminal tail containing six lysine residues. Lixisenatide has a…

Subcutaneous injection (daily)
MetabolicFDA Approved

Setmelanotide (Imcivree)

A cyclic peptide melanocortin-4 receptor (MC4R) agonist designed to restore MC4R signaling in patients with obesity caused by genetic deficiencies in…

Subcutaneous injection (daily)
HormoneFDA Approved

Sermorelin

A synthetic 29-amino acid analog of GHRH representing the shortest fully functional fragment of the native 44-amino acid hormone. Sermorelin…

Subcutaneous injection
HormoneFDA Approved

Tesamorelin (Egrifta)

A synthetic GHRH analog consisting of the 44-amino acid sequence of human GHRH with a trans-3-hexenoic acid modification at the N-terminus to improve…

Subcutaneous injection (daily)
HormoneFDA Approved

PT-141 (Bremelanotide / Vyleesi)

A synthetic cyclic heptapeptide melanocortin receptor agonist that activates MC3R and MC4R in the central nervous system. Unlike PDE5 inhibitors that…

Subcutaneous injection (as needed)
HormoneFDA Approved

Oxytocin

A nine-amino acid cyclic neuropeptide produced in the hypothalamus and released from the posterior pituitary. Oxytocin mediates uterine contractions…

Intravenous, Intramuscular injection, Intranasal
HormoneFDA Approved

Macimorelin (Macrilen)

An orally bioavailable growth hormone secretagogue approved as a diagnostic agent for adult growth hormone deficiency (AGHD). Macimorelin stimulates…

Oral
HormoneFDA Approved

Cosyntropin (Cortrosyn)

A synthetic peptide consisting of the first 24 amino acids of the 39-amino acid adrenocorticotropic hormone (ACTH). Cosyntropin retains full…

Intravenous, Intramuscular injection
HormoneFDA Approved

Gonadorelin (GnRH)

A synthetic decapeptide identical to endogenous gonadotropin-releasing hormone. Gonadorelin stimulates the release of luteinizing hormone (LH) and…

Intravenous, Subcutaneous injection
ReproductiveFDA Approved

Leuprolide (Lupron)

A synthetic nonapeptide GnRH agonist approximately 15-fold more potent than native GnRH. After an initial stimulatory phase (flare effect) lasting…

Subcutaneous injection, Intramuscular injection (depot)
ReproductiveFDA Approved

Goserelin (Zoladex)

A synthetic decapeptide GnRH agonist administered as a biodegradable subcutaneous implant that provides sustained drug release over 1 or 3 months.…

Subcutaneous implant
ReproductiveFDA Approved

Cetrorelix (Cetrotide)

A synthetic decapeptide GnRH antagonist that competitively blocks pituitary GnRH receptors, producing immediate and dose-dependent suppression of LH…

Subcutaneous injection
ReproductiveFDA Approved

Ganirelix

A synthetic decapeptide GnRH antagonist that competitively and reversibly blocks GnRH receptors on pituitary gonadotroph cells. Ganirelix rapidly…

Subcutaneous injection
AntimicrobialFDA Approved

Enfuvirtide (Fuzeon)

A 36-amino acid synthetic peptide that inhibits HIV-1 entry into CD4+ T-cells by blocking the gp41-mediated membrane fusion step. Enfuvirtide binds…

Subcutaneous injection (twice daily)
BoneFDA Approved

Teriparatide (Forteo)

A recombinant form of the first 34 amino acids of human parathyroid hormone (PTH 1-34). When administered intermittently via daily subcutaneous…

Subcutaneous injection (daily)
BoneFDA Approved

Abaloparatide (Tymlos)

A synthetic 34-amino acid peptide analog of parathyroid hormone-related protein (PTHrP 1-34) that selectively activates the RG conformation of the…

Subcutaneous injection (daily)
BoneFDA Approved

Calcitonin

A 32-amino acid peptide hormone naturally produced by parafollicular C-cells of the thyroid gland. Calcitonin inhibits osteoclast-mediated bone…

Intranasal, Subcutaneous injection, Intramuscular injection
BoneFDA Approved

Vosoritide (Voxzogo)

A C-type natriuretic peptide (CNP) analog that acts as an agonist at the natriuretic peptide receptor B (NPR-B) on growth plate chondrocytes.…

Subcutaneous injection (daily)
RenalFDA Approved

Vasopressin (ADH)

A nine-amino acid cyclic peptide hormone (arginine vasopressin) produced in the hypothalamus and released from the posterior pituitary. Vasopressin…

Intravenous, Intramuscular injection, Subcutaneous injection
RenalFDA Approved

Desmopressin (DDAVP)

A synthetic analog of vasopressin with enhanced V2 receptor selectivity and minimal V1a vasopressor activity. Desmopressin has a deaminated cysteine…

Intranasal, Oral, Subcutaneous injection, Intravenous
RenalFDA Approved

Terlipressin

A synthetic vasopressin analog and prodrug that is cleaved by endopeptidases to release lysine-vasopressin. Terlipressin has greater V1a receptor…

Intravenous
CardiovascularFDA Approved

Eptifibatide (Integrilin)

A synthetic cyclic heptapeptide modeled after the KGD (Lys-Gly-Asp) disintegrin sequence found in the venom of the southeastern pygmy rattlesnake…

Intravenous
CardiovascularFDA Approved

Nesiritide (Natrecor)

A recombinant form of human B-type natriuretic peptide (BNP), a 32-amino acid peptide naturally produced by ventricular cardiomyocytes in response to…

Intravenous
CardiovascularFDA Approved

Angiotensin II (Giapreza)

A synthetic form of the endogenous octapeptide angiotensin II, the primary effector of the renin-angiotensin system. Angiotensin II acts on AT1…

Intravenous
HematologyFDA Approved

Bivalirudin (Angiomax)

A synthetic 20-amino acid peptide that acts as a direct thrombin inhibitor by binding both the catalytic active site and anion-binding exosite 1 of…

Intravenous
HematologyFDA Approved

Romiplostim (Nplate)

A thrombopoietin (TPO) receptor agonist consisting of a peptide sequence that binds the TPO receptor (c-Mpl) fused to an IgG1 Fc domain (peptibody).…

Subcutaneous injection (weekly)
HematologyFDA Approved

Pegcetacoplan (Empaveli)

A pegylated cyclic peptide that inhibits complement component C3, the central node of all three complement activation pathways (classical, lectin…

Subcutaneous infusion
OncologyFDA Approved

Carfilzomib (Kyprolis)

A tetrapeptide epoxyketone proteasome inhibitor that irreversibly binds the chymotrypsin-like (beta5) subunit of the 20S proteasome. By blocking…

Intravenous

All 265 peptides

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The information provided by the Peptide Association is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified, licensed healthcare provider before beginning any peptide therapy, supplement regimen, or making changes to an existing treatment plan.

Peptide therapies discussed on this site may not be FDA-approved for all listed indications. Individual results vary. The Peptide Association does not prescribe, diagnose, or treat any medical condition. Clinicians in our network are independently licensed practitioners; the Association reviews licensure but does not employ or directly supervise these clinicians.

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