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The compound database

Peptide Database

264 therapeutic peptides with research summaries, clinical findings, and regulatory status. Every claim is cited.

FDA-approved
90
FDA-approved
Awaiting FDA
8
Awaiting FDA
No lawful pathway
166
No lawful pathway
1–36 of 90 · FDA ApprovedClear filters
  1. 001

    Pentosan Polysulfate (Elmiron)

    A semi-synthetic sulfated polysaccharide (not a peptide) derived from beechwood hemicellulose, with structural similarity to glycosaminoglycans and heparin.…

    Recovery · FDA Approved · Oral

    FDA-approved
  2. 002

    Semaglutide (Ozempic/Wegovy)

    A glucagon-like peptide-1 receptor agonist (GLP-1 RA) that differs from native GLP-1 by two amino acid substitutions (about 94% sequence identity) plus a fatty…

    Metabolic · FDA Approved · Subcutaneous injection (weekly), Oral (daily - Rybelsus)

    FDA-approved
  3. 003

    Tirzepatide (Mounjaro/Zepbound)

    A once-weekly dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. Tirzepatide activates both incretin pathways, and in…

    Metabolic · FDA Approved · Subcutaneous injection (weekly)

    FDA-approved
  4. 004

    Liraglutide (Saxenda/Victoza)

    A GLP-1 receptor agonist with 97% homology to native GLP-1, modified with a 16-carbon fatty acid chain that binds albumin and protects against DPP-4…

    Metabolic · FDA Approved · Subcutaneous injection (daily)

    FDA-approved
  5. 005

    Exenatide (Byetta/Bydureon)

    A synthetic version of exendin-4, a 39-amino acid peptide originally isolated from the venom of the Gila monster lizard (Heloderma suspectum). Exenatide shares…

    Metabolic · FDA Approved · Subcutaneous injection (twice daily or weekly extended-release)

    FDA-approved
  6. 006

    Glucagon

    A 29-amino acid peptide hormone produced by alpha cells of the pancreatic islets of Langerhans. Glucagon acts on the liver via the glucagon receptor (GCGR), a…

    Metabolic · FDA Approved · Subcutaneous injection, Intramuscular injection, Intranasal

    FDA-approved
  7. 007

    Pramlintide (Symlin)

    A synthetic analog of amylin (islet amyloid polypeptide), a 37-amino acid peptide hormone co-secreted with insulin from pancreatic beta cells. Pramlintide has…

    Metabolic · FDA Approved · Subcutaneous injection (before meals)

    FDA-approved
  8. 008

    Dulaglutide (Trulicity)

    A long-acting GLP-1 receptor agonist consisting of a GLP-1 analog fused to a modified human IgG4 Fc fragment, a design that retained full receptor activity…

    Metabolic · FDA Approved · Subcutaneous injection (weekly)

    FDA-approved
  9. 009

    Lixisenatide (Adlyxin)

    A selective GLP-1 receptor agonist derived from exendin-4 with a modified C-terminal tail containing six lysine residues. Lixisenatide increases…

    Metabolic · FDA Approved · Subcutaneous injection (daily)

    FDA-approved
  10. 010

    Setmelanotide (Imcivree)

    A cyclic peptide melanocortin-4 receptor (MC4R) agonist designed to restore MC4R signaling in patients with obesity caused by genetic defects in the…

    Metabolic · FDA Approved · Subcutaneous injection (daily)

    FDA-approved
  11. 011

    Sermorelin

    A synthetic 29-amino acid analog of GHRH corresponding to the shortest fully functional fragment of the native 44-amino acid hormone. Sermorelin stimulates…

    Hormone · FDA Approved · Subcutaneous injection

    FDA-approved
  12. 012

    Tesamorelin (Egrifta)

    A synthetic GHRH analog consisting of the full 44-amino acid sequence of human GHRH with a trans-3-hexenoic acid modification at the N-terminus to improve…

    Hormone · FDA Approved · Subcutaneous injection (daily)

    FDA-approved
  13. 013

    PT-141 (Bremelanotide / Vyleesi)

    A synthetic cyclic heptapeptide melanocortin receptor agonist structurally related to melanotan II. Unlike PDE5 inhibitors that act peripherally on vascular…

    Hormone · FDA Approved · Subcutaneous injection (as needed)

    FDA-approved
  14. 014

    Oxytocin

    A nine-amino acid cyclic neuropeptide produced mainly in the hypothalamus and released from the posterior pituitary in response to stimuli such as suckling…

    Hormone · FDA Approved · Intravenous, Intramuscular injection, Intranasal

    FDA-approved
  15. 015

    Macimorelin (Macrilen)

    An orally active ghrelin mimetic and growth hormone secretagogue developed as a diagnostic agent for adult growth hormone deficiency (AGHD). Macimorelin…

    Hormone · FDA Approved · Oral

    FDA-approved
  16. 016

    Cosyntropin (Cortrosyn)

    A synthetic peptide consisting of the first 24 amino acids of the 39-amino acid adrenocorticotropic hormone (ACTH). Cosyntropin reproduces the…

    Hormone · FDA Approved · Intravenous, Intramuscular injection

    FDA-approved
  17. 017

    Gonadorelin (GnRH)

    A synthetic decapeptide identical to endogenous gonadotropin-releasing hormone. A pulsatile pattern of GnRH is required for pituitary stimulation and release…

    Hormone · FDA Approved · Intravenous, Subcutaneous injection

    FDA-approved
  18. 018

    Leuprolide (Lupron)

    A synthetic nonapeptide GnRH agonist that is more potent and longer-acting than native GnRH. After an initial stimulatory phase (flare effect), chronic…

    Reproductive · FDA Approved · Subcutaneous injection, Intramuscular injection (depot)

    FDA-approved
  19. 019

    Goserelin (Zoladex)

    A synthetic decapeptide GnRH agonist administered as a biodegradable subcutaneous implant that provides sustained drug release over 1 or 3 months. Like other…

    Reproductive · FDA Approved · Subcutaneous implant

    FDA-approved
  20. 020

    Cetrorelix (Cetrotide)

    A synthetic decapeptide GnRH antagonist that competitively blocks pituitary GnRH receptors, rapidly suppressing LH and FSH without the initial flare effect…

    Reproductive · FDA Approved · Subcutaneous injection

    FDA-approved
  21. 021

    Ganirelix

    A synthetic decapeptide GnRH antagonist that competitively and reversibly blocks GnRH receptors on pituitary gonadotroph cells. GnRH antagonists such as…

    Reproductive · FDA Approved · Subcutaneous injection

    FDA-approved
  22. 022

    SS-31 (Elamipretide)

    A mitochondria-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that selectively binds cardiolipin in the inner mitochondrial membrane. In laboratory…

    Longevity · FDA Approved · Subcutaneous injection, Intravenous

    FDA-approved
  23. 023

    Enfuvirtide (Fuzeon)

    A 36-amino acid synthetic peptide that inhibits HIV-1 entry into CD4+ T-cells by blocking gp41-mediated membrane fusion. Enfuvirtide binds the first heptad…

    Antimicrobial · FDA Approved · Subcutaneous injection (twice daily)

    FDA-approved
  24. 024

    Teriparatide (Forteo)

    A recombinant form of the first 34 amino acids of human parathyroid hormone (PTH 1-34). When given intermittently by daily subcutaneous injection, teriparatide…

    Bone · FDA Approved · Subcutaneous injection (daily)

    FDA-approved
  25. 025

    Abaloparatide (Tymlos)

    A synthetic 34-amino acid peptide analog of parathyroid hormone-related protein (PTHrP 1-34). In cell studies abaloparatide binds more selectively than PTH…

    Bone · FDA Approved · Subcutaneous injection (daily)

    FDA-approved
  26. 026

    Calcitonin

    A 32-amino acid peptide hormone naturally produced by the parafollicular C-cells of the thyroid gland. Calcitonin inhibits osteoclast activity, reducing bone…

    Bone · FDA Approved · Intranasal, Subcutaneous injection, Intramuscular injection

    FDA-approved
  27. 027

    Vosoritide (Voxzogo)

    A C-type natriuretic peptide (CNP) analog that acts as an agonist at natriuretic peptide receptor B (NPR-B) on growth plate chondrocytes. Achondroplasia is…

    Bone · FDA Approved · Subcutaneous injection (daily)

    FDA-approved
  28. 028

    Vasopressin (ADH)

    A nine-amino acid cyclic peptide hormone (arginine vasopressin) produced in the hypothalamus and released from the posterior pituitary. Vasopressin acts on V1a…

    Renal · FDA Approved · Intravenous, Intramuscular injection, Subcutaneous injection

    FDA-approved
  29. 029

    Desmopressin (DDAVP)

    A synthetic analog of vasopressin (1-deamino-8-D-arginine vasopressin) with selective V2 receptor activity and minimal vasopressor activity. The deamination at…

    Renal · FDA Approved · Intranasal, Oral, Subcutaneous injection, Intravenous

    FDA-approved
  30. 030

    Terlipressin

    A synthetic vasopressin analog and prodrug that is converted in the body to lysine-vasopressin. Terlipressin acts mainly on V1 receptors to constrict…

    Renal · FDA Approved · Intravenous

    FDA-approved
  31. 031

    Eptifibatide (Integrilin)

    A synthetic cyclic heptapeptide modeled on barbourin, a disintegrin from the venom of the southeastern pygmy rattlesnake (Sistrurus miliarius barbouri) that…

    Cardiovascular · FDA Approved · Intravenous

    FDA-approved
  32. 032

    Nesiritide (Natrecor)

    A recombinant form of human B-type natriuretic peptide (BNP), a 32-amino acid peptide produced by ventricular cardiomyocytes in response to volume overload and…

    Cardiovascular · FDA Approved · Intravenous

    FDA-approved
  33. 033

    Angiotensin II (Giapreza)

    A synthetic form of the endogenous octapeptide angiotensin II, the main effector of the renin-angiotensin system. Angiotensin II acts on AT1 receptors on…

    Cardiovascular · FDA Approved · Intravenous

    FDA-approved
  34. 034

    Bivalirudin (Angiomax)

    A synthetic 20-amino acid peptide analog of hirudin that acts as a specific, reversible direct thrombin inhibitor, binding both fluid-phase and clot-bound…

    Hematology · FDA Approved · Intravenous

    FDA-approved
  35. 035

    Romiplostim (Nplate)

    A thrombopoietin (TPO) receptor agonist built as a peptibody: TPO-mimetic peptides fused to the Fc portion of human IgG1. It has a similar mechanism of action…

    Hematology · FDA Approved · Subcutaneous injection (weekly)

    FDA-approved
  36. 036

    Pegcetacoplan (Empaveli)

    A pegylated cyclic peptide that inhibits complement component C3 and C3b, acting upstream of C5 in the complement cascade. Because C5 inhibitors control…

    Hematology · FDA Approved · Subcutaneous infusion

    FDA-approved

Index · all 264 peptides, A–Z

Important Medical Disclaimer

The information provided by the Peptide Association is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified, licensed healthcare provider before beginning any peptide therapy, supplement regimen, or making changes to an existing treatment plan.

Peptide therapies discussed on this site may not be FDA-approved for all listed indications. Individual results vary. The Peptide Association does not prescribe, diagnose, or treat any medical condition. Clinicians in our network are independently licensed practitioners; the Association checks each clinician’s NPI record but does not employ or directly supervise these clinicians.

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