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Peptide Database

265 therapeutic peptides with research summaries, clinical findings, and regulatory status.

Showing 1–13 of 13 in AntimicrobialClear filters
AntimicrobialFDA Approved

Enfuvirtide (Fuzeon)

A 36-amino acid synthetic peptide that inhibits HIV-1 entry into CD4+ T-cells by blocking the gp41-mediated membrane fusion step. Enfuvirtide binds…

Subcutaneous injection (twice daily)
AntimicrobialResearch Phase

Magainin 2

Magainin 2 is a 23-amino acid antimicrobial peptide originally isolated from the skin of the African clawed frog Xenopus laevis. It exerts…

Topical
AntimicrobialIn Clinical Trials

Pexiganan (MSI-78)

Pexiganan is a 22-amino acid synthetic analog of magainin 2 designed to enhance antimicrobial potency and proteolytic stability. It disrupts…

Topical
AntimicrobialIn Clinical Trials

Omiganan

Omiganan is a synthetic 12-amino acid cationic antimicrobial peptide derived from indolicidin, a naturally occurring peptide from bovine neutrophils.…

Topical
AntimicrobialInvestigational

Iseganan (IB-367)

Iseganan is a 17-amino acid synthetic analog of protegrin, a naturally occurring antimicrobial peptide found in porcine leukocytes. It disrupts…

Oral rinse
AntimicrobialResearch Phase

Defensin HNP-1

Human neutrophil peptide 1 (HNP-1) is a 30-amino acid alpha-defensin produced by neutrophils as part of the innate immune response. It contains three…

Topical, Intravenous
AntimicrobialResearch Phase

Alpha-Defensin 5

Alpha-defensin 5 (HD5) is a 32-amino acid cationic peptide predominantly expressed by Paneth cells in the small intestinal crypts. It contains three…

Oral, Topical
AntimicrobialInvestigational

Lactoferricin

Lactoferricin is a cationic antimicrobial peptide derived from pepsin-mediated cleavage of lactoferrin, an iron-binding glycoprotein found in milk…

Oral, Topical
AntimicrobialInvestigational

Nisin

Nisin is a 34-amino acid polycyclic antibacterial peptide (lantibiotic) produced by Lactococcus lactis. It disrupts bacterial cell wall synthesis and…

Topical, Oral
AntimicrobialInvestigational

Gramicidin S

Gramicidin S is a cyclic decapeptide antibiotic isolated from Bacillus brevis, consisting of two identical pentapeptide sequences joined in a ring…

Topical
AntimicrobialFDA Approved

Polymyxin B

Polymyxin B is a cyclic lipopeptide antibiotic derived from Bacillus polymyxa, consisting of a heptapeptide ring and a tripeptide side chain acylated…

Intravenous, Intrathecal, Topical
AntimicrobialFDA Approved

Colistin (Polymyxin E)

Colistin, also known as polymyxin E, is a cyclic polypeptide antibiotic structurally similar to polymyxin B, produced by Paenibacillus polymyxa. It…

Intravenous, Intramuscular, Inhalation
AntimicrobialResearch Phase

Indolicidin

Indolicidin is a 13-amino acid antimicrobial peptide derived from bovine neutrophils, characterized by a high tryptophan content (five residues). It…

Topical

All 265 peptides

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Peptide therapies discussed on this site may not be FDA-approved for all listed indications. Individual results vary. The Peptide Association does not prescribe, diagnose, or treat any medical condition. Clinicians in our network are independently licensed practitioners; the Association reviews licensure but does not employ or directly supervise these clinicians.

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