Vasopressin (ADH)
Overview
A nine-amino acid cyclic peptide hormone (arginine vasopressin) produced in the hypothalamus and released from the posterior pituitary. Vasopressin acts on V1a receptors (vascular smooth muscle vasoconstriction), V1b receptors (ACTH release from pituitary), and V2 receptors (aquaporin-2 insertion in renal collecting ducts for water reabsorption).
Mechanism of Action
It is essential for body water homeostasis and hemodynamic stability.
Research Summary & Key Findings
FDA-approved for diabetes insipidus, prevention and treatment of postoperative abdominal distention, and as a vasopressor in vasodilatory shock. VASST trial evaluated vasopressin vs. norepinephrine in septic shock with inconclusive primary outcome but benefit in less severe sepsis subgroup (Russell et al., NEJM, 2008). Recommended in ACLS guidelines as an alternative to epinephrine in cardiac arrest.
Clinical Status
Vasopressin (ADH) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.
Administration Routes
References
Primary literature
- PubMed — "Vasopressin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Vasopressin"
Registered interventional and observational studies, including status and phase.
- PubChem — "Vasopressin"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
Related Peptides in Renal
Desmopressin (DDAVP)
FDA ApprovedA synthetic analog of vasopressin with enhanced V2 receptor selectivity and minimal V1a vasopressor activity. Desmopress...
View detailsTerlipressin
FDA ApprovedA synthetic vasopressin analog and prodrug that is cleaved by endopeptidases to release lysine-vasopressin. Terlipressin...
View detailsStart Your Consultation
Get an AI-proposed Vasopressin (ADH) protocol reviewed by a physician in our network.
Start Your ConsultationFind a Pharmacy
Browse PCAB-accredited and FDA 503B-registered compounding pharmacies that supply Vasopressin (ADH).
Pharmacy DirectoryJoin the Association
Access exclusive peptide protocols, provider resources, and community support.
List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.