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VIP (Vasoactive Intestinal Peptide)
Overview
A 28-amino acid neuropeptide widely distributed in the central and peripheral nervous systems and immune cells. VIP acts through VPAC1 and VPAC2 receptors to produce potent anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-12) and promoting regulatory T-cell differentiation.
Mechanism of Action
It also functions as a vasodilator, bronchodilator, and neuromodulator.
Research Summary & Key Findings
Clinical research by Dr. Shoemaker demonstrated efficacy in chronic inflammatory response syndrome (CIRS) associated with mold exposure. VIP nasal spray reduced markers of inflammation including TGF-beta-1, MMP-9, and C4a. Studies show neuroprotective effects and potential application in pulmonary hypertension and sarcoidosis.
Clinical Status
VIP (Vasoactive Intestinal Peptide) is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
References
Primary literature
- PubMed: "VIP"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "VIP"
Registered interventional and observational studies, including status and phase.
- PubChem: "VIP"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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View detailsNo lawful pathway today
VIP (Vasoactive Intestinal Peptide) is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
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List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.