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HormoneFDA Approved

Gonadorelin (GnRH)

Intravenous, Subcutaneous injection
Written by Peptide Association Editorial TeamMedically reviewed by Ian Justl Ellis, MD, CPTLast reviewed Editorial policy

Overview

A synthetic decapeptide identical to endogenous gonadotropin-releasing hormone. Gonadorelin stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary when administered in a pulsatile fashion.

Mechanism of Action

Continuous or high-dose administration paradoxically downregulates GnRH receptors, suppressing gonadotropin secretion, a principle exploited by GnRH agonist therapeutics.

Research Summary & Key Findings

FDA-approved for diagnostic evaluation of hypothalamic-pituitary-gonadal axis function and for induction of ovulation. Pulsatile GnRH pump therapy successfully restores fertility in hypothalamic amenorrhea patients. The diagnostic test measures LH response to distinguish hypothalamic from pituitary causes of hypogonadism.

Clinical Status

FDA Approved

Gonadorelin (GnRH) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

IntravenousSubcutaneous injection

References

Primary literature

Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.