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DermatologyInvestigational

Rigin (Palmitoyl Tetrapeptide-7)

Topical
Written by Peptide Association Editorial TeamMedically reviewed by Ian Justl Ellis, MD, CPTLast reviewed Editorial policy

Overview

Rigin is a lipopeptide composed of the tetrapeptide sequence Gly-Gln-Pro-Arg conjugated to palmitic acid. It is designed to reduce production of interleukin-6 and other pro-inflammatory cytokines in dermal fibroblasts, thereby mitigating chronic low-grade inflammation associated with skin aging.

Mechanism of Action

By modulating the inflammatory microenvironment, the peptide is proposed to support matrix integrity and reduce glycation-induced damage.

Research Summary & Key Findings

In vitro studies using UV-irradiated or cytokine-stimulated fibroblasts have demonstrated that palmitoyl tetrapeptide-7 reduces IL-6 secretion and restores collagen synthesis. Industry-sponsored trials, often in combination with palmitoyl tripeptide-1 (Matrixyl 3000), have reported improvements in skin firmness and wrinkle depth, though isolated effects of Rigin are not well characterized. Independent peer-reviewed clinical data remain limited.

Clinical Status

Investigational

Rigin (Palmitoyl Tetrapeptide-7) is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.

Administration Routes

Topical

References

Primary literature

Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.