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Semax
Overview
A synthetic heptapeptide analog of the ACTH(4-7) fragment (Met-Glu-His-Phe-Pro-Gly-Pro) with nootropic and neuroprotective properties. Semax modulates BDNF and NGF expression, enhances monoaminergic neurotransmission, and provides neuroprotection through anti-oxidant and anti-inflammatory mechanisms.
Mechanism of Action
It crosses the blood-brain barrier via intranasal administration.
Research Summary & Key Findings
Approved in Russia and Ukraine for treatment of stroke, cognitive disorders, and optic nerve disease. Clinical studies demonstrated improved memory, attention, and cognitive performance. Research shows upregulation of BDNF and trkB expression in the hippocampus and cortex.
Clinical Status
Semax is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
References
Primary literature
- PubMed: "Semax"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Semax"
Registered interventional and observational studies, including status and phase.
- PubChem: "Semax"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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