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RecoveryResearch Phase

DSIP (Delta Sleep-Inducing Peptide)

Subcutaneous injection, Intravenous, Intranasal
Written by Peptide Association Editorial TeamMedically reviewed by Ian Justl Ellis, MD, CPTLast reviewed Editorial policy

Overview

A naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from cerebral venous blood of rabbits during induced sleep. DSIP modulates sleep architecture by promoting delta wave (slow-wave) sleep through interactions with the GABAergic system and hypothalamic sleep centers.

Mechanism of Action

It also exhibits stress-protective, analgesic, and neuromodulatory properties.

Research Summary & Key Findings

Clinical studies showed normalization of disturbed sleep patterns in insomnia patients without next-day sedation. Demonstrated reduction in stress-related corticotropin levels. Limited clinical data but preclinical models show consistent sleep-promoting and neuroprotective effects.

Clinical Status

Research Phase

DSIP (Delta Sleep-Inducing Peptide) is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.

Administration Routes

Subcutaneous injectionIntravenousIntranasal

References

Primary literature

Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.