Cognitive · Research Phase
N-acetyl Selank Amidate
No lawful US pathway
01 · Overview
N-acetyl Selank Amidate is a modified form of Selank, a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) built on the immunomodulatory peptide tuftsin with an added Pro-Gly-Pro sequence (PMID 11550013). The acetylation and amidation are intended to increase stability, but this has not been demonstrated in published studies.
For parent Selank, proposed mechanisms include inhibition of enkephalin-degrading enzymes in human plasma (PMID 11550013) and allosteric modulation of GABA receptor binding in rat brain membranes (PMID 30255741). The peptide has been explored for anxiety, cognitive enhancement, and stress adaptation.
02 · Research summary & key findings
No peer-reviewed studies of the acetylated and amidated analog itself were found in PubMed; the findings below concern parent Selank. In rats with chronic alcohol exposure, Selank prevented memory and attention impairment and normalized brain BDNF levels (PMID 31625062). A Russian clinical study of 62 patients with generalized anxiety disorder or neurasthenia found anxiolytic effects similar to the benzodiazepine medazepam, with additional anti-asthenic effects (PMID 18454096). A US clinical pharmacology review described Selank as a poorly studied Russian drug with GABAergic activity sold to US consumers as a supplement (PMID 34396551). Neither Selank nor its analog is approved by the FDA.
03 · Regulatory status
N-acetyl Selank Amidate is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
No lawful pathway today
N-acetyl Selank Amidate is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so we do not sell it and will not book a consultation for it. That can change: in 2026 FDA began reviewing several peptides for compounding. If you are working on the goal it is studied for, a licensed clinician can tell you what is lawfully available, which may be something else.
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Looking for a lawful, clinician-prescribed option for cognitive support?
N-acetyl Selank Amidate is a research compound, is not FDA-approved, and has no lawful US compounding pathway, so we do not offer it and no clinician we work with will prescribe it. Products sold online as “research chemicals” are not made or tested to the standards required of medicines. If you are working on cognitive support, a licensed clinician can tell you at a free consultation whether an FDA-approved or lawfully compounded treatment fits you, or whether nothing does.
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04 · Administration routes
- Intranasal
References
- [1]The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity Bull Exp Biol Med, 2001. PMID 11550013
- [2][Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia] Zh Nevrol Psikhiatr Im S S Korsakova, 2008. PMID 18454096
- [3]Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity Protein Pept Lett, 2018. PMID 30255741
- [4]Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats Bull Exp Biol Med, 2019. PMID 31625062
- [5]Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank J Clin Pharmacol, 2021. PMID 34396551
Primary literature
- PubMed: "N-acetyl Selank Amidate"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "N-acetyl Selank Amidate"
Registered interventional and observational studies, including status and phase.
- PubChem: "N-acetyl Selank Amidate"
Chemical structure, molecular properties, and bioactivity data.
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