ARA-290
Overview
A synthetic 11-amino acid peptide derived from the structure of erythropoietin (EPO) that selectively activates the innate repair receptor (IRR), a heteromer of the EPO receptor and the beta common receptor (CD131). Unlike EPO, ARA-290 does not stimulate erythropoiesis or promote thrombosis.
Mechanism of Action
It produces cytoprotective, anti-inflammatory, and tissue-reparative effects by activating the IRR on neurons, immune cells, and endothelial cells.
Research Summary & Key Findings
Phase 2 trials in patients with sarcoidosis-related small fiber neuropathy showed significant improvement in corneal nerve fiber density and reduction in neuropathic pain (Dahan et al., Mol Med, 2013). Preclinical studies demonstrated neuroprotective effects in diabetic neuropathy and cardiac ischemia-reperfusion injury. The selective IRR activation without erythropoietic effects avoids the thrombotic risks that limited EPO-based neuroprotection strategies.
Clinical Status
ARA-290 is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.
Administration Routes
References
Primary literature
- PubMed — "ARA-290"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "ARA-290"
Registered interventional and observational studies, including status and phase.
- PubChem — "ARA-290"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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