Nesiritide (Natrecor)
Overview
A recombinant form of human B-type natriuretic peptide (BNP), a 32-amino acid peptide naturally produced by ventricular cardiomyocytes in response to volume overload and wall stress.
Mechanism of Action
Nesiritide binds natriuretic peptide receptor A (NPR-A), activating guanylyl cyclase and increasing intracellular cGMP to produce venous, arterial, and coronary vasodilation, natriuresis, and suppression of the renin-angiotensin-aldosterone and sympathetic nervous systems.
Research Summary & Key Findings
FDA-approved in 2001 for acutely decompensated heart failure with dyspnea at rest. ASCEND-HF trial (2011) showed modest improvement in dyspnea but no reduction in mortality or rehospitalization, with trends toward worsening renal function and hypotension. Use has declined significantly in favor of other heart failure therapies. Remains available but relegated to second-line status by current guidelines.
Clinical Status
Nesiritide (Natrecor) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.
Administration Routes
References
Primary literature
- PubMed — "Nesiritide"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Nesiritide"
Registered interventional and observational studies, including status and phase.
- PubChem — "Nesiritide"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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