GHRH (Sermorelin 1-44)
Overview
Sermorelin is a synthetic 44-amino acid peptide corresponding to the biologically active portion of human growth hormone releasing hormone (GHRH). It stimulates endogenous growth hormone secretion from the anterior pituitary by binding to GHRH receptors.
Mechanism of Action
Originally approved for diagnostic testing of growth hormone secretion, sermorelin was subsequently marketed for treatment of growth hormone deficiency in children before being voluntarily withdrawn.
Research Summary & Key Findings
FDA approval was granted in 1997 under the brand name Geref for diagnostic use and later extended to therapeutic indications in pediatric growth hormone deficiency. The manufacturer discontinued sermorelin acetate in the mid-2000s for business reasons unrelated to safety or efficacy. Clinical evidence demonstrated physiologic growth hormone stimulation, though it has been largely supplanted by recombinant growth hormone products.
Clinical Status
GHRH (Sermorelin 1-44) is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
References
Primary literature
- PubMed — "GHRH"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "GHRH"
Registered interventional and observational studies, including status and phase.
- PubChem — "GHRH"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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CJC-1295
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