Selank
Overview
A synthetic analog of the endogenous tetrapeptide tuftsin (Thr-Lys-Pro-Arg) with an added Pro-Gly-Pro sequence for stability. Selank exhibits anxiolytic activity comparable to benzodiazepines without sedation, dependence, or withdrawal effects.
Mechanism of Action
It modulates the expression of BDNF, serotonin, dopamine, and norepinephrine, and influences IL-6 and GABA receptor expression.
Research Summary & Key Findings
Approved in Russia for generalized anxiety disorder and as a nootropic. Clinical trials showed anxiolytic effects comparable to medazepam without sedation. Demonstrated immunomodulatory properties through modulation of IL-6 and T-helper cell balance.
Clinical Status
Selank is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
References
Primary literature
- PubMed — "Selank"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Selank"
Registered interventional and observational studies, including status and phase.
- PubChem — "Selank"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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