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The compound database

Peptide Databasepage 2

264 therapeutic peptides with research summaries, clinical findings, and regulatory status. Every claim is cited.

FDA-approved
90
FDA-approved
Awaiting FDA
8
Awaiting FDA
No lawful pathway
166
No lawful pathway
37–72 of 90 · FDA ApprovedClear filters
  1. 037

    Carfilzomib (Kyprolis)

    A tetrapeptide epoxyketone proteasome inhibitor that binds the proteasome irreversibly, with minimal off-target inhibition of other proteases in preclinical…

    Oncology · FDA Approved · Intravenous

    FDA-approved
  2. 038

    Bortezomib (Velcade)

    A dipeptidyl boronic acid that selectively and reversibly inhibits the 26S proteasome, disrupting the ubiquitin-proteasome pathway that degrades many…

    Oncology · FDA Approved · Subcutaneous injection, Intravenous

    FDA-approved
  3. 039

    Lutetium-177 dotatate (Lutathera)

    A radiolabeled somatostatin analog consisting of the peptide DOTA-Tyr3-octreotate chelated to the beta-emitting radioisotope lutetium-177. It binds…

    Oncology · FDA Approved · Intravenous

    FDA-approved
  4. 040

    Leuprolide (Lupron) - Oncology

    A GnRH agonist used in oncology for androgen deprivation therapy (ADT) in prostate cancer. Continuous administration downregulates pituitary GnRH receptors…

    Oncology · FDA Approved · Intramuscular injection (depot), Subcutaneous injection

    FDA-approved
  5. 041

    Octreotide (Sandostatin)

    A synthetic eight-amino acid analog of somatostatin with a much longer duration of action than native somatostatin, whose very short half-life requires…

    Gastrointestinal · FDA Approved · Subcutaneous injection, Intramuscular injection (LAR), Intravenous

    FDA-approved
  6. 042

    Lanreotide (Somatuline Depot)

    A synthetic octapeptide analog of somatostatin with high affinity for SSTR2 and lower affinity for SSTR5. The long-acting formulation (Autogel, sold in the US…

    Gastrointestinal · FDA Approved · Deep subcutaneous injection (monthly)

    FDA-approved
  7. 043

    Pasireotide (Signifor)

    A multireceptor-targeted somatostatin analog with affinity for SSTR1, SSTR2, SSTR3 and SSTR5, including high affinity for SSTR5. Corticotroph adenomas in…

    Gastrointestinal · FDA Approved · Subcutaneous injection (twice daily), Intramuscular injection (monthly LAR)

    FDA-approved
  8. 044

    Plecanatide (Trulance)

    A synthetic 16-amino acid analog of uroguanylin, an endogenous intestinal peptide that regulates fluid and electrolyte balance in the GI tract. Plecanatide…

    Gastrointestinal · FDA Approved · Oral

    FDA-approved
  9. 045

    Linaclotide (Linzess)

    A synthetic 14-amino acid peptide structurally related to the heat-stable enterotoxin of Escherichia coli and the endogenous peptide guanylin. Linaclotide is a…

    Gastrointestinal · FDA Approved · Oral

    FDA-approved
  10. 046

    Secretin

    A 27-amino acid peptide hormone produced by S-cells of the duodenal and jejunal mucosa in response to acid entering the small intestine. Secretin stimulates…

    Gastrointestinal · FDA Approved · Intravenous

    FDA-approved
  11. 047

    Ziconotide (Prialt)

    A synthetic 25-amino acid peptide identical to omega-conotoxin MVIIA from the venom of the marine cone snail Conus magus. Ziconotide potently and selectively…

    Pain · FDA Approved · Intrathecal infusion

    FDA-approved
  12. 048

    Difelikefalin (Korsuva)

    A peripherally restricted, selective kappa-opioid receptor (KOR) agonist peptide developed to reduce itch. Its limited central nervous system penetration is…

    Pain · FDA Approved · Intravenous (post-dialysis)

    FDA-approved
  13. 049

    Afamelanotide (Scenesse)

    A synthetic 13-amino acid analog of alpha-melanocyte-stimulating hormone (alpha-MSH), [Nle4-D-Phe7]-alpha-MSH, with norleucine at position 4 and…

    Dermatology · FDA Approved · Subcutaneous implant

    FDA-approved
  14. 050

    Pentagastrin

    A synthetic pentapeptide containing the C-terminal tetrapeptide sequence of gastrin (Trp-Met-Asp-Phe-NH2) linked to beta-alanine. Pentagastrin stimulates…

    Diagnostic · FDA Approved · Subcutaneous injection, Intramuscular injection

    FDA-approved
  15. 051

    Icatibant (Firazyr)

    A synthetic decapeptide bradykinin B2 receptor antagonist containing five non-natural amino acids for enhanced stability and receptor selectivity. Icatibant…

    Immune · FDA Approved · Subcutaneous injection

    FDA-approved
  16. 052

    Orforglipron

    Orforglipron is a non-peptide, oral small-molecule glucagon-like peptide-1 receptor (GLP-1R) agonist developed as an alternative to injectable GLP-1 drugs. It…

    Metabolic · FDA Approved · Oral

    FDA-approved
  17. 053

    Teduglutide (Gattex)

    Teduglutide is a recombinant analogue of human glucagon-like peptide-2 (GLP-2) comprising 33 amino acids with a single amino acid substitution that confers…

    Metabolic · FDA Approved · Subcutaneous injection

    FDA-approved
  18. 054

    Albiglutide (Tanzeum)

    Albiglutide is a GLP-1 receptor agonist made of modified human GLP-1 sequences fused to human albumin, giving it an elimination half-life of about 5 days that…

    Metabolic · FDA Approved · Subcutaneous injection

    FDA-approved
  19. 055

    Enlicitide

    Enlicitide (enlicitide decanoate, formerly MK-0616) is an oral macrocyclic peptide that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9)…

    Metabolic · FDA Approved · Oral

    FDA-approved
  20. 056

    Somatropin (Genotropin)

    Somatropin is recombinant human growth hormone (rhGH) consisting of 191 amino acids identical in sequence to endogenous pituitary growth hormone. It binds to…

    Hormone · FDA Approved · Subcutaneous injection

    FDA-approved
  21. 057

    Somapacitan (Sogroya)

    Somapacitan is a long-acting growth hormone derivative engineered to bind reversibly to albumin, which extends its half-life to allow once-weekly subcutaneous…

    Hormone · FDA Approved · Subcutaneous injection

    FDA-approved
  22. 058

    Lonapegsomatropin (Skytrofa)

    Lonapegsomatropin is a long-acting prodrug of somatropin in which growth hormone is transiently linked to a polyethylene glycol carrier through a cleavable…

    Hormone · FDA Approved · Subcutaneous injection

    FDA-approved
  23. 059

    Pegvisomant (Somavert)

    Pegvisomant is a PEGylated growth hormone receptor antagonist engineered from human growth hormone with amino acid substitutions that confer antagonist…

    Hormone · FDA Approved · Subcutaneous injection

    FDA-approved
  24. 060

    Mecasermin (Increlex)

    Mecasermin is recombinant human insulin-like growth factor 1 (IGF-1) consisting of 70 amino acids identical to the endogenous peptide hormone. It binds to…

    Hormone · FDA Approved · Subcutaneous injection

    FDA-approved
  25. 061

    GHRH (Sermorelin 1-44)

    Growth hormone releasing hormone (GHRH) is a 44-amino acid hypothalamic peptide that stimulates growth hormone secretion from the anterior pituitary by binding…

    Hormone · FDA Approved · Subcutaneous injection

    FDA-approved
  26. 062

    Sinapultide (KL4 Surfactant)

    Sinapultide (KL4) is a synthetic 21-amino acid peptide that mimics surfactant protein B, a critical component of pulmonary surfactant. Combined with…

    Recovery · FDA Approved · Intratracheal instillation

    FDA-approved
  27. 063

    OP-1 / BMP-7

    OP-1, or osteogenic protein-1, is the recombinant form of bone morphogenetic protein-7 (BMP-7), a member of the transforming growth factor-beta superfamily.…

    Recovery · FDA Approved · Implantation at surgical site

    FDA-approved
  28. 064

    Brain Natriuretic Peptide (BNP)

    Brain natriuretic peptide, despite its name, is a 32-amino acid hormone secreted predominantly by ventricular cardiomyocytes in response to increased wall…

    Cardiovascular · FDA Approved · Intravenous

    FDA-approved
  29. 065

    Degarelix (Firmagon)

    Degarelix is a synthetic decapeptide gonadotropin-releasing hormone (GnRH) receptor antagonist used for advanced prostate cancer, marketed as Firmagon. Unlike…

    Oncology · FDA Approved · Subcutaneous injection

    FDA-approved
  30. 066

    Triptorelin (Trelstar)

    Triptorelin is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH) that acts as a long-acting agonist. After an initial stimulatory…

    Oncology · FDA Approved · Intramuscular injection

    FDA-approved
  31. 067

    Histrelin (Vantas)

    Histrelin is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH) that functions as a GnRH agonist. It is delivered by a subcutaneous…

    Oncology · FDA Approved · Subcutaneous implant

    FDA-approved
  32. 068

    Abarelix (Plenaxis)

    Abarelix is a synthetic decapeptide that functions as a gonadotropin-releasing hormone (GnRH) receptor antagonist. Because it blocks pituitary GnRH receptors…

    Oncology · FDA Approved · Intramuscular injection

    FDA-approved
  33. 069

    Elagolix (Orilissa)

    Elagolix is an orally administered small-molecule, non-peptide gonadotropin-releasing hormone (GnRH) receptor antagonist. While not a peptide itself, it blocks…

    Oncology · FDA Approved · Oral

    FDA-approved
  34. 070

    Relugolix (Orgovyx)

    Relugolix is an orally active non-peptide gonadotropin-releasing hormone (GnRH) receptor antagonist. Although it is not a peptide, it acts through the same…

    Oncology · FDA Approved · Oral

    FDA-approved
  35. 071

    177Lu-PSMA-617 (Pluvicto)

    177Lu-PSMA-617 (lutetium Lu 177 vipivotide tetraxetan) is a radioligand therapy that pairs a small urea-based peptidomimetic ligand for prostate-specific…

    Oncology · FDA Approved · Intravenous

    FDA-approved
  36. 072

    Tirbanibulin (Klisyri)

    Tirbanibulin is a synthetic small-molecule (non-peptide) inhibitor of tubulin polymerization and Src kinase signaling. It is applied topically as a 1% ointment…

    Oncology · FDA Approved · Topical

    FDA-approved

Index · all 264 peptides, A–Z

Important Medical Disclaimer

The information provided by the Peptide Association is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified, licensed healthcare provider before beginning any peptide therapy, supplement regimen, or making changes to an existing treatment plan.

Peptide therapies discussed on this site may not be FDA-approved for all listed indications. Individual results vary. The Peptide Association does not prescribe, diagnose, or treat any medical condition. Clinicians in our network are independently licensed practitioners; the Association checks each clinician’s NPI record but does not employ or directly supervise these clinicians.

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