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Peptide DatabasePage 2

265 therapeutic peptides with research summaries, clinical findings, and regulatory status.

Showing 37–72 of 86 with status FDA ApprovedClear filters
OncologyFDA Approved

Bortezomib (Velcade)

A modified dipeptidyl boronic acid that reversibly inhibits the chymotrypsin-like activity of the 26S proteasome. Bortezomib disrupts the…

Subcutaneous injection, Intravenous
OncologyFDA Approved

Lutetium-177 dotatate (Lutathera)

A radiolabeled somatostatin analog consisting of the peptide DOTA-Tyr3-octreotate chelated to the beta-emitting radioisotope lutetium-177. Lutathera…

Intravenous
OncologyFDA Approved

Leuprolide (Lupron) - Oncology

A GnRH agonist used in oncology for androgen deprivation therapy (ADT) in prostate cancer and hormone suppression in premenopausal breast cancer.…

Intramuscular injection (depot), Subcutaneous injection
GastrointestinalFDA Approved

Octreotide (Sandostatin)

A synthetic octapeptide analog of somatostatin with a substantially longer half-life (90 minutes IV, 6 hours subcutaneous vs. 2 minutes for native…

Subcutaneous injection, Intramuscular injection (LAR), Intravenous
GastrointestinalFDA Approved

Lanreotide (Somatuline Depot)

A synthetic octapeptide analog of somatostatin with high affinity for SSTR2 and moderate affinity for SSTR5 receptors. Lanreotide is formulated as a…

Deep subcutaneous injection (monthly)
GastrointestinalFDA Approved

Pasireotide (Signifor)

A multireceptor-targeted somatostatin analog with high binding affinity for SSTR1, SSTR2, SSTR3, and SSTR5, particularly notable for its 40-fold…

Subcutaneous injection (twice daily), Intramuscular injection (monthly LAR)
GastrointestinalFDA Approved

Plecanatide (Trulance)

A synthetic 16-amino acid peptide structurally related to uroguanylin, an endogenous intestinal peptide that regulates fluid and electrolyte…

Oral
GastrointestinalFDA Approved

Linaclotide (Linzess)

A synthetic 14-amino acid peptide structurally related to the heat-stable enterotoxin of Escherichia coli and the endogenous peptide guanylin.…

Oral
GastrointestinalFDA Approved

Secretin

A 27-amino acid peptide hormone produced by S-cells of the duodenal and jejunal mucosa in response to acidic chyme entering the small intestine.…

Intravenous
PainFDA Approved

Ziconotide (Prialt)

A synthetic 25-amino acid peptide identical to omega-conotoxin MVIIA, a neurotoxin found in the venom of the marine cone snail Conus magus.…

Intrathecal infusion
PainFDA Approved

Difelikefalin (Korsuva)

A selective kappa-opioid receptor (KOR) agonist peptide that does not cross the blood-brain barrier, providing peripheral analgesia and anti-pruritic…

Intravenous (post-dialysis)
DermatologyFDA Approved

Afamelanotide (Scenesse)

A synthetic 13-amino acid analog of alpha-melanocyte-stimulating hormone (alpha-MSH) with a substitution of norleucine at position 4 that confers…

Subcutaneous implant
DiagnosticFDA Approved

Pentagastrin

A synthetic pentapeptide containing the C-terminal tetrapeptide sequence of gastrin (Trp-Met-Asp-Phe-NH2) linked to beta-alanine. Pentagastrin…

Subcutaneous injection, Intramuscular injection
ImmuneFDA Approved

Icatibant (Firazyr)

A synthetic decapeptide bradykinin B2 receptor antagonist containing five non-natural amino acids for enhanced stability and receptor selectivity.…

Subcutaneous injection
MetabolicFDA Approved

Teduglutide (Gattex)

Teduglutide is a recombinant analogue of human glucagon-like peptide-2 (GLP-2) comprising 33 amino acids with a single amino acid substitution that…

Subcutaneous injection
MetabolicFDA Approved

Albiglutide (Tanzeum)

Albiglutide is a GLP-1 receptor agonist consisting of a tandem repeat of modified human GLP-1 sequences fused to human albumin, creating a protein of…

Subcutaneous injection
HormoneFDA Approved

Capromorelin (Entyce)

Capromorelin is a selective ghrelin receptor agonist, or growth hormone secretagogue, that mimics the endogenous peptide hormone ghrelin by binding…

Oral
HormoneFDA Approved

Somatropin (Genotropin)

Somatropin is recombinant human growth hormone (rhGH) consisting of 191 amino acids identical in sequence to endogenous pituitary growth hormone. It…

Subcutaneous injection
HormoneFDA Approved

Somapacitan (Sogroya)

Somapacitan is a long-acting growth hormone analogue engineered by attaching an albumin-binding moiety to recombinant human growth hormone. This…

Subcutaneous injection
HormoneFDA Approved

Lonapegsomatropin (Skytrofa)

Lonapegsomatropin is a long-acting prodrug of somatropin created through site-specific PEGylation that releases active growth hormone after…

Subcutaneous injection
HormoneFDA Approved

Pegvisomant (Somavert)

Pegvisomant is a PEGylated growth hormone receptor antagonist engineered from human growth hormone with nine amino acid substitutions that confer…

Subcutaneous injection
HormoneFDA Approved

Mecasermin (Increlex)

Mecasermin is recombinant human insulin-like growth factor 1 (IGF-1) consisting of 70 amino acids identical to the endogenous peptide hormone. It…

Subcutaneous injection
RecoveryFDA Approved

OP-1 / BMP-7

OP-1, or osteogenic protein-1, is the recombinant form of bone morphogenetic protein-7 (BMP-7), a member of the transforming growth factor-beta…

Implantation at surgical site
CardiovascularFDA Approved

Brain Natriuretic Peptide (BNP)

Brain natriuretic peptide, despite its name, is a 32-amino acid hormone secreted predominantly by ventricular cardiomyocytes in response to…

Intravenous
OncologyFDA Approved

Degarelix (Firmagon)

Degarelix is a synthetic decapeptide gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of advanced prostate cancer.…

Subcutaneous injection
OncologyFDA Approved

Triptorelin (Trelstar)

Triptorelin is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH) that functions as a long-acting GnRH agonist. Following an…

Intramuscular injection
OncologyFDA Approved

Histrelin (Vantas)

Histrelin is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH) that functions as a GnRH agonist. The peptide is administered…

Subcutaneous implant
OncologyFDA Approved

Abarelix (Plenaxis)

Abarelix is a synthetic decapeptide that functions as a gonadotropin-releasing hormone (GnRH) receptor antagonist. It competitively blocks pituitary…

Intramuscular injection
OncologyFDA Approved

Elagolix (Orilissa)

Elagolix is a small molecule non-peptide gonadotropin-releasing hormone (GnRH) receptor antagonist administered orally. While not a peptide itself…

Oral
OncologyFDA Approved

Relugolix (Orgovyx)

Relugolix is an orally bioavailable non-peptide gonadotropin-releasing hormone (GnRH) receptor antagonist. Although it is not a peptide, it exerts…

Oral
OncologyFDA Approved

177Lu-PSMA-617 (Pluvicto)

177Lu-PSMA-617 is a radioligand therapeutic consisting of a small peptide-based ligand targeting prostate-specific membrane antigen (PSMA) conjugated…

Intravenous
OncologyFDA Approved

Somatostatin (Native)

Somatostatin is a naturally occurring cyclic tetradecapeptide hormone produced by neuroendocrine cells throughout the body, including the…

Intravenous
OncologyFDA Approved

Tirbanibulin (Klisyri)

Tirbanibulin is a small molecule synthetic peptide mimetic that inhibits tubulin polymerization and disrupts Src kinase signaling pathways. It is…

Topical
GastrointestinalFDA Approved

Cholecystokinin (CCK)

Cholecystokinin is an endogenous peptide hormone existing in multiple forms, most commonly as CCK-8 and CCK-33, secreted by I-cells in the duodenum…

Intravenous
AntimicrobialFDA Approved

Polymyxin B

Polymyxin B is a cyclic lipopeptide antibiotic derived from Bacillus polymyxa, consisting of a heptapeptide ring and a tripeptide side chain acylated…

Intravenous, Intrathecal, Topical
AntimicrobialFDA Approved

Colistin (Polymyxin E)

Colistin, also known as polymyxin E, is a cyclic polypeptide antibiotic structurally similar to polymyxin B, produced by Paenibacillus polymyxa. It…

Intravenous, Intramuscular, Inhalation

All 265 peptides

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Peptide therapies discussed on this site may not be FDA-approved for all listed indications. Individual results vary. The Peptide Association does not prescribe, diagnose, or treat any medical condition. Clinicians in our network are independently licensed practitioners; the Association reviews licensure but does not employ or directly supervise these clinicians.

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