Reproductive · FDA Approved
Choriogonadotropin Alfa (Ovidrel)
FDA-approved
01 · Overview
Choriogonadotropin alfa is a recombinant human chorionic gonadotropin produced in Chinese hamster ovary cells. The heterodimeric glycoprotein binds the LH/hCG receptor on ovarian granulosa and theca cells to trigger final oocyte maturation and ovulation.
It is used in assisted reproductive technology to time oocyte retrieval and in ovulation induction. The product Ovidrel was approved under BLA 021149 and remains listed as a prescription product in the FDA drug approval database, with some presentations discontinued.
02 · Research summary & key findings
FDA approval was granted in September 2000 according to the FDA drug approval database. A Cochrane review of 18 randomized trials in 2952 women found no conclusive difference between recombinant hCG and urinary hCG for triggering final oocyte maturation, with similar ongoing pregnancy and live birth rates (PMID 27106604). The practical argument for the recombinant product is consistency and removal of urinary contaminants rather than higher pregnancy rates (PMID 27106604). It is now a standard option in ovulation induction and IVF protocols.
03 · Regulatory status
Choriogonadotropin Alfa (Ovidrel) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.
Choriogonadotropin Alfa (Ovidrel) is an FDA-approved medicine prescribed for the conditions on its label. It is not part of our intake, so we do not propose protocols for it. If you think it may be relevant to you, talk to your own doctor. How to ask your doctor.
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Choriogonadotropin Alfa (Ovidrel) is prescribed for the conditions on its label, and it is not part of our intake. If you are working on hormone optimization, a licensed clinician can tell you at a free consultation whether an FDA-approved or lawfully compounded treatment fits you, or whether nothing does.
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04 · Administration routes
- Subcutaneous injection
References
- [1]Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles Cochrane Database Syst Rev, 2016. PMID 27106604
Primary literature
- PubMed: "Choriogonadotropin Alfa"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Choriogonadotropin Alfa"
Registered interventional and observational studies, including status and phase.
- PubChem: "Choriogonadotropin Alfa"
Chemical structure, molecular properties, and bioactivity data.
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