Atrial Natriuretic Peptide (ANP)
Overview
Atrial natriuretic peptide is a 28-amino acid endogenous hormone secreted primarily by atrial cardiomyocytes in response to atrial stretch and volume expansion. It binds to natriuretic peptide receptor A, activating guanylyl cyclase to produce cyclic GMP, which mediates vasodilation, natriuresis, and inhibition of aldosterone and renin secretion.
Mechanism of Action
ANP plays a critical role in cardiovascular homeostasis and blood pressure regulation.
Research Summary & Key Findings
ANP is an endogenous regulatory peptide rather than a therapeutic agent itself, though its recombinant form carperitide is approved in Japan. Plasma ANP levels serve as a biomarker in heart failure assessment, with elevations correlating with disease severity and prognosis in numerous observational studies.
Clinical Status
Atrial Natriuretic Peptide (ANP) is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
References
Primary literature
- PubMed — "Atrial Natriuretic Peptide"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Atrial Natriuretic Peptide"
Registered interventional and observational studies, including status and phase.
- PubChem — "Atrial Natriuretic Peptide"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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