Granulysin
Overview
Granulysin is a 15-kDa antimicrobial and cytolytic protein expressed by cytotoxic T lymphocytes and natural killer cells. It disrupts microbial and tumor cell membranes via lipid interactions and induces apoptosis.
Mechanism of Action
The therapeutic rationale includes treatment of intracellular infections and cancer immunotherapy.
Research Summary & Key Findings
Preclinical studies have shown granulysin-mediated killing of mycobacteria, including Mycobacterium tuberculosis, as well as antitumor activity in vitro and in animal models. No clinical trials or approved formulations are currently available, and development remains at the research stage.
Clinical Status
Granulysin is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
References
Primary literature
- PubMed — "Granulysin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Granulysin"
Registered interventional and observational studies, including status and phase.
- PubChem — "Granulysin"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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