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Urocortin 2
Overview
Urocortin 2 is a 38-amino acid peptide member of the corticotropin-releasing factor family with selective affinity for CRF receptor 2. It exerts cardiovascular effects including coronary and peripheral vasodilation, increased cardiac contractility, and protection against ischemia-reperfusion injury through receptor-mediated cyclic AMP signaling.
Mechanism of Action
The selective receptor profile distinguishes it from urocortin 1 and may offer advantages in minimizing stress-axis activation.
Research Summary & Key Findings
Preclinical studies in animal models have demonstrated that urocortin 2 improves cardiac output and reduces myocardial injury in heart failure and ischemia models. Limited early-phase human data exist, and the peptide remains in the research phase without published clinical efficacy trials for cardiovascular indications.
Clinical Status
Urocortin 2 is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
References
Primary literature
- PubMed: "Urocortin 2"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Urocortin 2"
Registered interventional and observational studies, including status and phase.
- PubChem: "Urocortin 2"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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View detailsNo lawful pathway today
Urocortin 2 is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
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List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.