Urocortin 2
Overview
Urocortin 2 is a 38-amino acid peptide member of the corticotropin-releasing factor family with selective affinity for CRF receptor 2. It exerts cardiovascular effects including coronary and peripheral vasodilation, increased cardiac contractility, and protection against ischemia-reperfusion injury through receptor-mediated cyclic AMP signaling.
Mechanism of Action
The selective receptor profile distinguishes it from urocortin 1 and may offer advantages in minimizing stress-axis activation.
Research Summary & Key Findings
Preclinical studies in animal models have demonstrated that urocortin 2 improves cardiac output and reduces myocardial injury in heart failure and ischemia models. Limited early-phase human data exist, and the peptide remains in the research phase without published clinical efficacy trials for cardiovascular indications.
Clinical Status
Urocortin 2 is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
References
Primary literature
- PubMed — "Urocortin 2"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Urocortin 2"
Registered interventional and observational studies, including status and phase.
- PubChem — "Urocortin 2"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
Related Peptides in Cardiovascular
Eptifibatide (Integrilin)
FDA ApprovedA synthetic cyclic heptapeptide modeled after the KGD (Lys-Gly-Asp) disintegrin sequence found in the venom of the south...
View detailsNesiritide (Natrecor)
FDA ApprovedA recombinant form of human B-type natriuretic peptide (BNP), a 32-amino acid peptide naturally produced by ventricular ...
View detailsAngiotensin II (Giapreza)
FDA ApprovedA synthetic form of the endogenous octapeptide angiotensin II, the primary effector of the renin-angiotensin system. Ang...
View detailsSerelaxin (Relaxin-2)
InvestigationalSerelaxin is a recombinant form of human relaxin-2, a naturally occurring peptide hormone composed of two chains linked ...
View detailsStart Your Consultation
Get an AI-proposed Urocortin 2 protocol reviewed by a physician in our network.
Start Your ConsultationFind a Pharmacy
Browse PCAB-accredited and FDA 503B-registered compounding pharmacies that supply Urocortin 2.
Pharmacy DirectoryJoin the Association
Access exclusive peptide protocols, provider resources, and community support.
List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.