Goserelin (Zoladex)
Overview
A synthetic decapeptide GnRH agonist administered as a biodegradable subcutaneous implant that provides sustained drug release over 1 or 3 months. Like other GnRH agonists, goserelin initially stimulates and then suppresses the HPG axis, reducing sex hormone production to castrate or postmenopausal levels.
Mechanism of Action
The implant formulation eliminates the need for repeated injections and ensures compliance.
Research Summary & Key Findings
FDA-approved for prostate cancer, breast cancer, endometriosis, and endometrial thinning. The 10.8 mg depot provides 3 months of sustained hormone suppression. Equivalent efficacy to surgical castration in prostate cancer with the advantage of reversibility. Used as adjuvant therapy with radiation in locally advanced prostate cancer based on landmark trials (Bolla et al., NEJM, 1997).
Clinical Status
Goserelin (Zoladex) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.
Administration Routes
References
Primary literature
- PubMed — "Goserelin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Goserelin"
Registered interventional and observational studies, including status and phase.
- PubChem — "Goserelin"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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