Orexin B
Overview
Orexin B is a 28-amino acid neuropeptide closely related to orexin A, also synthesized in hypothalamic neurons and involved in promoting wakefulness and regulating feeding behavior. It exhibits preferential binding to orexin receptor 2 (OX2R) compared to OX1R.
Mechanism of Action
Orexin B contributes to the maintenance of arousal and the integration of metabolic and circadian signals.
Research Summary & Key Findings
Animal studies have shown that orexin B administration promotes wakefulness and reduces sleep latency, with effects generally considered less potent than orexin A in arousal models. Published data in sleep research and endocrinology journals support its role in vigilance state control. As with orexin A, poor pharmacokinetic properties and blood-brain barrier limitations have precluded clinical development of the native peptide.
Clinical Status
Orexin B is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
References
Primary literature
- PubMed — "Orexin B"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Orexin B"
Registered interventional and observational studies, including status and phase.
- PubChem — "Orexin B"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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