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Alpha-MSH
Overview
Alpha-melanocyte-stimulating hormone (alpha-MSH) is a 13-amino-acid peptide derived from proopiomelanocortin (POMC). It acts via melanocortin receptors to exert potent anti-inflammatory and immunomodulatory effects, including suppression of proinflammatory cytokines and inhibition of nuclear factor kappa B (NF-kB).
Mechanism of Action
Therapeutic interest spans inflammatory and autoimmune disorders.
Research Summary & Key Findings
Preclinical models have demonstrated efficacy in reducing inflammation in conditions such as colitis, arthritis, and uveitis. Clinical translation has been limited, with synthetic analogs under exploration, but no large-scale trials or approvals for alpha-MSH itself have been reported.
Clinical Status
Alpha-MSH is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
References
Primary literature
- PubMed: "Alpha-MSH"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Alpha-MSH"
Registered interventional and observational studies, including status and phase.
- PubChem: "Alpha-MSH"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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View detailsNo lawful pathway today
Alpha-MSH is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
Tell me if the status changes
One email, only if this compound's regulatory standing actually moves. Not a newsletter, not a sales sequence.
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List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.