CJC-1295
Overview
A synthetic analog of growth hormone-releasing hormone (GHRH) with a Drug Affinity Complex (DAC) that binds to albumin, extending its half-life from minutes to approximately 6-8 days.
Mechanism of Action
CJC-1295 stimulates pulsatile GH release from the anterior pituitary by binding to GHRH receptors while preserving the natural GH secretory pattern and negative feedback mechanisms.
Research Summary & Key Findings
Phase II clinical data showed sustained 2-3 fold increases in GH and IGF-1 levels for 6+ days after a single injection. Well-tolerated with dose-dependent effects on body composition parameters including lean mass gains.
Clinical Status
CJC-1295 is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.
Administration Routes
References
Primary literature
- PubMed — "CJC-1295"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "CJC-1295"
Registered interventional and observational studies, including status and phase.
- PubChem — "CJC-1295"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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