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Dermorphin
Overview
Dermorphin is a heptapeptide opioid agonist originally isolated from the skin of South American Phyllomedusa frogs. It exhibits high selectivity and affinity for the mu-opioid receptor, with potency approximately 30 to 40 times greater than morphine in animal models.
Mechanism of Action
The unique D-alanine residue at position 2 confers resistance to peptidase degradation and contributes to its prolonged analgesic activity. Its potent receptor binding has made it a valuable research tool for studying opioid receptor pharmacology.
Research Summary & Key Findings
Preclinical studies in rodents have demonstrated potent antinociceptive effects following intracerebroventricular and systemic administration. Dermorphin has been used extensively in laboratory settings to map mu-opioid receptor distribution and function. No human clinical trials have been conducted, and its use remains confined to experimental neuropharmacology research.
Clinical Status
Dermorphin is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
References
Primary literature
- PubMed: "Dermorphin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Dermorphin"
Registered interventional and observational studies, including status and phase.
- PubChem: "Dermorphin"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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View detailsNo lawful pathway today
Dermorphin is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
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List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.