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Apraglutide
Overview
Apraglutide is a long-acting glucagon-like peptide-2 (GLP-2) receptor agonist designed to promote intestinal growth and improve absorption in patients with short bowel syndrome. The peptide analogue shares structural homology with native GLP-2 but incorporates modifications that extend its half-life and enhance resistance to dipeptidyl peptidase-4 degradation.
Mechanism of Action
By binding to GLP-2 receptors in the intestinal epithelium, apraglutide stimulates crypt cell proliferation and reduces gastric emptying and secretion, supporting adaptive intestinal function.
Research Summary & Key Findings
Phase 3 trials in adults with short bowel syndrome dependent on parenteral support have demonstrated significant reductions in parenteral nutrition volume requirements compared to placebo. The compound has been studied primarily in patients with remnant colon or jejunostomy configurations, with published data appearing in Gastroenterology and related specialty journals since 2020.
Clinical Status
Apraglutide is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.
Administration Routes
References
Primary literature
- PubMed: "Apraglutide"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Apraglutide"
Registered interventional and observational studies, including status and phase.
- PubChem: "Apraglutide"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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View detailsNo lawful pathway today
Apraglutide is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
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List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.