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Uroguanylin (Dolcanatide)
Overview
Uroguanylin is a 16-amino acid endogenous peptide structurally related to guanylin that also activates guanylate cyclase-C receptors in the intestinal epithelium. It regulates fluid and electrolyte secretion in the gut and plays a role in satiety signaling and metabolic homeostasis.
Mechanism of Action
The synthetic analog dolcanatide has been developed to mimic uroguanylin's effects with enhanced stability and bioavailability. Like guanylin, uroguanylin increases cyclic GMP levels, promoting intestinal secretion and motility.
Research Summary & Key Findings
Dolcanatide has been evaluated in clinical trials for chronic constipation and constipation-predominant irritable bowel syndrome, demonstrating improved bowel function in early-phase studies. A phase 2 trial published in 2011 showed dose-dependent increases in bowel movement frequency and stool consistency. Further clinical development has been limited, and the agent has not achieved regulatory approval.
Clinical Status
Uroguanylin (Dolcanatide) is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.
Administration Routes
References
Primary literature
- PubMed: "Uroguanylin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Uroguanylin"
Registered interventional and observational studies, including status and phase.
- PubChem: "Uroguanylin"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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View detailsNo lawful pathway today
Uroguanylin (Dolcanatide) is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
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List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.