Dermatology · Investigational
Matrixyl 3000
No lawful US pathway
01 · Overview
Matrixyl 3000 is a proprietary combination of two lipopeptides, palmitoyl tripeptide-1 (Pal-GHK) and palmitoyl tetrapeptide-7 (Pal-GQPR), marketed to support extracellular matrix renewal and reduce visible signs of skin aging (PMID 42790608). The manufacturer describes the tetrapeptide component as reducing interleukin-6 mediated inflammation, but this has not been confirmed in independent peer-reviewed studies.
Both peptides carry palmitic acid to increase lipid solubility; in human volunteers, both were detected throughout the stratum corneum after topical application of a serum, at decreasing levels with depth, and appeared to stay on the outer surfaces of skin cells (PMID 42790608).
02 · Research summary & key findings
In a study of skin explants and volunteers, a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved dermal matrix structure versus placebo on confocal microscopy and ultrasound (PMID 25817264). A 12-week study of a multi-ingredient eye cream containing both peptides along with other actives reported improved hydration, elasticity, and ultrasound collagen density, though the peptides' individual contribution cannot be separated and the study had no placebo arm (PMID 38932444). A review of cosmetic peptides noted that most supporting data come from patents and supplier brochures rather than randomized placebo-controlled studies (PMID 34451799).
03 · Regulatory status
Matrixyl 3000 is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
No lawful pathway today
Matrixyl 3000 is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so we do not sell it and will not book a consultation for it. That can change: in 2026 FDA began reviewing several peptides for compounding. If you are working on the goal it is studied for, a licensed clinician can tell you what is lawfully available, which may be something else.
See the 1 FDA-approved compound in Dermatology
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Looking for a lawful, clinician-prescribed option for longevity and healthy ageing?
Matrixyl 3000 is an investigational compound, is not FDA-approved, and has no lawful US compounding pathway, so we do not offer it and no clinician we work with will prescribe it. Products sold online as “research chemicals” are not made or tested to the standards required of medicines. If you are working on longevity and healthy ageing, a licensed clinician can tell you at a free consultation whether an FDA-approved or lawfully compounded treatment fits you, or whether nothing does.
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04 · Administration routes
- Topical
References
- [1]Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications J Cosmet Dermatol, 2015. PMID 25817264
- [2]Usage of Synthetic Peptides in Cosmetics for Sensitive Skin Pharmaceuticals (Basel), 2021. PMID 34451799
- [3]Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream Skin Res Technol, 2024. PMID 38932444
- [4]Permeation behaviour of cosmetic actives into the human stratum corneum Int J Pharm, 2026. PMID 42790608
Primary literature
- PubMed: "Matrixyl 3000"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Matrixyl 3000"
Registered interventional and observational studies, including status and phase.
- PubChem: "Matrixyl 3000"
Chemical structure, molecular properties, and bioactivity data.
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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed. Clinicians: join the network.