Urocortin 1
Overview
Urocortin 1 is a 40-amino acid peptide belonging to the corticotropin-releasing factor (CRF) family. It binds to both CRF receptor 1 and CRF receptor 2 with high affinity, mediating diverse cardiovascular effects including vasodilation, positive inotropy, and cardioprotection.
Mechanism of Action
The peptide has demonstrated beneficial hemodynamic properties and anti-inflammatory actions in preclinical models of heart failure and ischemia-reperfusion injury.
Research Summary & Key Findings
Early phase clinical trials have evaluated urocortin 1 infusion in heart failure patients, demonstrating hemodynamic improvements including increased cardiac output and reduced systemic vascular resistance. However, no large-scale efficacy trials have been completed, and development for cardiovascular indications remains investigational.
Clinical Status
Urocortin 1 is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
References
Primary literature
- PubMed — "Urocortin 1"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Urocortin 1"
Registered interventional and observational studies, including status and phase.
- PubChem — "Urocortin 1"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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