Reproductive · FDA Approved
Menotropin (Menopur)
FDA-approved
01 · Overview
Menotropin is a purified preparation of human menopausal gonadotropins extracted from the urine of postmenopausal women, containing both follicle-stimulating hormone and luteinizing hormone activity. The combined FSH and LH activity supports follicular recruitment, granulosa cell proliferation and ovarian steroidogenesis.
It is used for ovulation induction in anovulatory infertility and for controlled ovarian stimulation in assisted reproduction. Menopur was approved under BLA 021663 and remains listed as a prescription product in the FDA drug approval database.
02 · Research summary & key findings
FDA approval of Menopur was granted in October 2004 according to the FDA drug approval database, and earlier menotropin products had been marketed for decades before that. A 2026 Cochrane review of randomized trials found that, compared with recombinant FSH, human menopausal gonadotropin or highly purified HMG was associated with probably higher live birth and clinical pregnancy rates and probably less ovarian hyperstimulation syndrome, although the certainty of this evidence was moderate and many trials were industry funded (PMID 42445958). A Cochrane network meta-analysis of stimulation protocols likewise found that in women predicted to be high responders on antagonist protocols, HMG may reduce ovarian hyperstimulation syndrome compared with recombinant FSH, while increasing cycle cancellation, both on low-certainty evidence from a single study (PMID 40590303). The agent remains widely used alongside recombinant alternatives.
03 · Regulatory status
Menotropin (Menopur) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.
Menotropin (Menopur) is an FDA-approved medicine prescribed for the conditions on its label. It is not part of our intake, so we do not propose protocols for it. If you think it may be relevant to you, talk to your own doctor. How to ask your doctor.
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Menotropin (Menopur) is prescribed for the conditions on its label, and it is not part of our intake. If you are working on hormone optimization, a licensed clinician can tell you at a free consultation whether an FDA-approved or lawfully compounded treatment fits you, or whether nothing does.
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04 · Administration routes
- Subcutaneous injection
- Intramuscular injection
References
- [1]Controlled ovarian stimulation protocols for assisted reproduction: a network meta-analysis Cochrane Database Syst Rev, 2025. PMID 40590303
- [2]Recombinant follicle-stimulating hormone (rFSH) versus other recombinant or urinary gonadotropins for ovarian stimulation in assisted reproductive technology cycles Cochrane Database Syst Rev, 2026. PMID 42445958
Primary literature
- PubMed: "Menotropin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Menotropin"
Registered interventional and observational studies, including status and phase.
- PubChem: "Menotropin"
Chemical structure, molecular properties, and bioactivity data.
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