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The compound database

Peptide Database

264 therapeutic peptides with research summaries, clinical findings, and regulatory status. Every claim is cited.

FDA-approved
90
FDA-approved
Awaiting FDA
8
Awaiting FDA
No lawful pathway
166
No lawful pathway
1–14 of 14 · PainClear filters
  1. 001

    Ziconotide (Prialt)

    A synthetic 25-amino acid peptide identical to omega-conotoxin MVIIA from the venom of the marine cone snail Conus magus. Ziconotide potently and selectively…

    Pain · FDA Approved · Intrathecal infusion

    FDA-approved
  2. 002

    Difelikefalin (Korsuva)

    A peripherally restricted, selective kappa-opioid receptor (KOR) agonist peptide developed to reduce itch. Its limited central nervous system penetration is…

    Pain · FDA Approved · Intravenous (post-dialysis)

    FDA-approved
  3. 003

    ARA-290

    A synthetic 11-amino acid peptide (also called cibinetide or pyroglutamate helix B surface peptide) modeled on the helix B region of erythropoietin (EPO) that…

    Pain · Investigational · Subcutaneous injection, Intravenous

    No lawful pathway
  4. 004

    Palmitoylethanolamide (PEA)

    An endogenous fatty acid amide belonging to the N-acylethanolamine family, produced by cells in response to tissue damage and inflammation. In mouse models…

    Pain · In Clinical Trials · Oral

    No lawful pathway
  5. 005

    Dynorphin A

    Dynorphin A is a 17-amino acid endogenous opioid peptide derived from prodynorphin that preferentially activates kappa-opioid receptors. Dynorphins are…

    Pain · Investigational · Endogenous peptide

    No lawful pathway
  6. 006

    Leu-Enkephalin

    Leu-enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Leu) identified in 1975 as one of the two enkephalins, natural ligands for opiate receptors. Enkephalins are…

    Pain · Research Phase · Endogenous peptide

    No lawful pathway
  7. 007

    Met-Enkephalin

    Met-enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met) that differs from leu-enkephalin only in its C-terminal amino acid. Enkephalins are regarded as…

    Pain · Investigational · Endogenous peptide

    No lawful pathway
  8. 008

    Endomorphin-1

    Endomorphin-1 is an amidated tetrapeptide (Tyr-Pro-Trp-Phe-NH2) isolated from brain in 1997 that binds the mu-opioid receptor with high affinity and about…

    Pain · Research Phase · Endogenous peptide

    No lawful pathway
  9. 009

    Endomorphin-2

    Endomorphin-2 is an amidated tetrapeptide (Tyr-Pro-Phe-Phe-NH2) that, like endomorphin-1, is a highly selective mu-opioid receptor agonist. The two…

    Pain · Research Phase · Endogenous peptide

    No lawful pathway
  10. 010

    Nociceptin / Orphanin FQ

    Nociceptin, also known as orphanin FQ (N/OFQ), is a 17-amino acid peptide identified in 1995 as the endogenous ligand of the opioid receptor-like ORL1…

    Pain · Investigational · Endogenous peptide

    No lawful pathway
  11. 011

    Conantokin-G

    Conantokin-G is a 17-amino acid peptide from the venom of the cone snail Conus geographus that acts as an NMDA receptor antagonist. In cells expressing defined…

    Pain · Investigational · Intrathecal, Intravenous

    No lawful pathway
  12. 012

    Dermorphin

    Dermorphin is a heptapeptide opioid agonist originally isolated from the skin of South American Phyllomedusa frogs. It is a selective mu-opioid receptor…

    Pain · Investigational · Intracerebroventricular, Subcutaneous injection

    No lawful pathway
  13. 013

    Deltorphin

    Deltorphin refers to a class of highly selective delta-opioid heptapeptides from the skin of the Amazonian frogs Phyllomedusa sauvagei and Phyllomedusa…

    Pain · Research Phase · Intracerebroventricular, Subcutaneous injection

    No lawful pathway
  14. 014

    Neuropeptide FF

    Neuropeptide FF (NPFF) is a member of the RFamide peptide family, characterized by an arginine-phenylalanine-amide motif at the C-terminus. It acts on the G…

    Pain · Research Phase · Intracerebroventricular, Subcutaneous injection

    No lawful pathway

Index · all 264 peptides, A–Z

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