Peptide Association LLC is a for-profit company. We receive compensation from the clinical providers listed on this site. We are not an accrediting body, a licensing board, or a government-affiliated organization. See exactly how we make money.

Peptide Database

265 therapeutic peptides with research summaries, clinical findings, and regulatory status.

Showing 1–14 of 14 in PainClear filters
PainFDA Approved

Ziconotide (Prialt)

A synthetic 25-amino acid peptide identical to omega-conotoxin MVIIA, a neurotoxin found in the venom of the marine cone snail Conus magus.…

Intrathecal infusion
PainFDA Approved

Difelikefalin (Korsuva)

A selective kappa-opioid receptor (KOR) agonist peptide that does not cross the blood-brain barrier, providing peripheral analgesia and anti-pruritic…

Intravenous (post-dialysis)
PainIn Clinical Trials

ARA-290

A synthetic 11-amino acid peptide derived from the structure of erythropoietin (EPO) that selectively activates the innate repair receptor (IRR), a…

Subcutaneous injection, Intravenous
PainResearch Phase

Palmitoylethanolamide (PEA)

An endogenous fatty acid amide belonging to the N-acylethanolamine family, naturally produced by cells in response to tissue damage and inflammation.…

Oral
PainResearch Phase

Dynorphin A

Dynorphin A is an endogenous opioid peptide of 17 amino acids that preferentially binds to and activates kappa-opioid receptors, though it also has…

Endogenous peptide
PainResearch Phase

Leu-Enkephalin

Leu-enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Leu) that functions as an endogenous opioid agonist with preferential activity at delta-opioid…

Endogenous peptide
PainResearch Phase

Met-Enkephalin

Met-enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met) that differs from leu-enkephalin only in its C-terminal amino acid. It acts as an endogenous…

Endogenous peptide
PainResearch Phase

Endomorphin-1

Endomorphin-1 is a tetrapeptide (Tyr-Pro-Trp-Phe) that exhibits highly selective agonist activity at the mu-opioid receptor, the primary target for…

Endogenous peptide
PainResearch Phase

Endomorphin-2

Endomorphin-2 is a tetrapeptide (Tyr-Pro-Phe-Phe) that, like endomorphin-1, demonstrates highly selective agonism at mu-opioid receptors. The two…

Endogenous peptide
PainResearch Phase

Nociceptin / Orphanin FQ

Nociceptin, also known as orphanin FQ, is a 17-amino acid peptide that acts as the endogenous ligand for the nociceptin/orphanin FQ peptide (NOP)…

Endogenous peptide
PainInvestigational

Conantokin-G

Conantokin-G is a 17-amino acid peptide originally isolated from the venom of the cone snail Conus geographus. It acts as a selective antagonist of…

Intrathecal, Intravenous
PainResearch Phase

Dermorphin

Dermorphin is a heptapeptide opioid agonist originally isolated from the skin of South American Phyllomedusa frogs. It exhibits high selectivity and…

Intracerebroventricular, Subcutaneous injection
PainResearch Phase

Deltorphin

Deltorphin is a heptapeptide opioid agonist also derived from Phyllomedusa frog skin secretions, characterized by high selectivity for delta-opioid…

Intracerebroventricular, Subcutaneous injection
PainResearch Phase

Neuropeptide FF

Neuropeptide FF (NPFF) is an octapeptide belonging to the RFamide family, characterized by an arginine-phenylalanine-amide motif at the C-terminus.…

Intracerebroventricular, Subcutaneous injection

All 265 peptides

Complete index, every profile, one click away.

Important Medical Disclaimer

The information provided by the Peptide Association is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified, licensed healthcare provider before beginning any peptide therapy, supplement regimen, or making changes to an existing treatment plan.

Peptide therapies discussed on this site may not be FDA-approved for all listed indications. Individual results vary. The Peptide Association does not prescribe, diagnose, or treat any medical condition. Clinicians in our network are independently licensed practitioners; the Association reviews licensure but does not employ or directly supervise these clinicians.

© 2026 The Peptide Association. All rights reserved. Content on this site is protected under applicable intellectual property laws. HIPAA-compliant infrastructure. The Peptide Association is not a medical practice.