KPV
Overview
A C-terminal tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone (alpha-MSH) that retains potent anti-inflammatory activity without melanogenic effects. KPV inhibits NF-kB nuclear translocation and reduces production of pro-inflammatory cytokines including TNF-alpha, IL-1beta, and IL-6.
Mechanism of Action
It penetrates cell membranes and directly interacts with inflammatory signaling cascades, making it effective topically and orally for mucosal inflammation.
Research Summary & Key Findings
Preclinical studies demonstrated significant anti-inflammatory effects in colitis models, reducing mucosal inflammation and promoting epithelial barrier repair. Oral KPV-loaded nanoparticles showed targeted anti-inflammatory activity in the colon (Dalmasso et al., PLoS One, 2008). Investigated for inflammatory bowel disease, atopic dermatitis, and wound healing. Preclinical stage with limited human clinical data.
Clinical Status
KPV is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
References
Primary literature
- PubMed — "KPV"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "KPV"
Registered interventional and observational studies, including status and phase.
- PubChem — "KPV"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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