Atosiban
Overview
A competitive oxytocin/vasopressin V1a receptor antagonist used as a tocolytic agent to delay preterm labor. Atosiban blocks oxytocin-mediated myometrial contractions without the cardiovascular side effects associated with beta-adrenergic tocolytics.
Mechanism of Action
The peptide is administered as an initial bolus followed by a step-down infusion protocol over up to 48 hours.
Research Summary & Key Findings
Approved in Europe and many countries worldwide (not FDA-approved in the US). Clinical trials demonstrated efficacy in delaying delivery by 48 hours to allow corticosteroid administration for fetal lung maturity. Superior safety profile compared to beta-agonist tocolytics, with significantly fewer maternal cardiovascular side effects (Flenady et al., Cochrane Review, 2014).
Clinical Status
Atosiban is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
References
Primary literature
- PubMed — "Atosiban"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Atosiban"
Registered interventional and observational studies, including status and phase.
- PubChem — "Atosiban"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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