Cotadutide
Overview
Cotadutide is a dual agonist of the GLP-1 and glucagon receptors formulated as a peptide for subcutaneous injection. It is designed to harness GLP-1-mediated improvements in glucose homeostasis and satiety alongside glucagon receptor activation to enhance energy expenditure and reduce hepatic fat.
Mechanism of Action
Primary indications under investigation include obesity, type 2 diabetes, and metabolic dysfunction-associated steatohepatitis.
Research Summary & Key Findings
Phase 2 studies in patients with type 2 diabetes and non-alcoholic fatty liver disease showed reductions in body weight and liver fat. Data presented at liver and diabetes conferences in 2019 and 2020 supported continued investigation. Development status and phase 3 plans have not been widely updated in recent literature.
Clinical Status
Cotadutide is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.
Administration Routes
References
Primary literature
- PubMed — "Cotadutide"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Cotadutide"
Registered interventional and observational studies, including status and phase.
- PubChem — "Cotadutide"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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