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Cotadutide
Overview
Cotadutide is a dual agonist of the GLP-1 and glucagon receptors formulated as a peptide for subcutaneous injection. It is designed to harness GLP-1-mediated improvements in glucose homeostasis and satiety alongside glucagon receptor activation to enhance energy expenditure and reduce hepatic fat.
Mechanism of Action
Primary indications under investigation include obesity, type 2 diabetes, and metabolic dysfunction-associated steatohepatitis.
Research Summary & Key Findings
Phase 2 studies in patients with type 2 diabetes and non-alcoholic fatty liver disease showed reductions in body weight and liver fat. Data presented at liver and diabetes conferences in 2019 and 2020 supported continued investigation. Development status and phase 3 plans have not been widely updated in recent literature.
Clinical Status
Cotadutide is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.
Administration Routes
References
Primary literature
- PubMed: "Cotadutide"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Cotadutide"
Registered interventional and observational studies, including status and phase.
- PubChem: "Cotadutide"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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View detailsNo lawful pathway today
Cotadutide is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
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One email, only if this compound's regulatory standing actually moves. Not a newsletter, not a sales sequence.
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List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.