Chrysalin (TP508)
Overview
Chrysalin, also known as TP508, is a 23-amino acid synthetic peptide derived from the receptor-binding domain of human thrombin. It is designed to activate non-proteolytic thrombin receptors on endothelial cells, fibroblasts, and osteoblasts, thereby promoting angiogenesis, granulation tissue formation, and bone repair.
Mechanism of Action
The peptide retains thrombin's tissue repair signaling properties without procoagulant activity.
Research Summary & Key Findings
Phase II trials in diabetic foot ulcers and fracture healing showed some evidence of accelerated wound closure and callus formation. However, subsequent phase III trials did not demonstrate statistically significant improvements in primary endpoints, and commercial development has been limited.
Clinical Status
Chrysalin (TP508) is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
References
Primary literature
- PubMed — "Chrysalin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Chrysalin"
Registered interventional and observational studies, including status and phase.
- PubChem — "Chrysalin"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
Related Peptides in Recovery
BPC-157
Research PhaseA synthetic gastric pentadecapeptide derived from a protein found in human gastric juice. BPC-157 promotes angiogenesis ...
View detailsTB-500 (Thymosin Beta-4)
In Clinical TrialsThymosin Beta-4 is a 43-amino acid actin-sequestering protein involved in cell migration, differentiation, and tissue re...
View detailsGHK-Cu
Research PhaseA naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine) found in human plasma, saliva, and urine. G...
View detailsDSIP (Delta Sleep-Inducing Peptide)
Research PhaseA naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from cerebral venous blood o...
View detailsStart Your Consultation
Get an AI-proposed Chrysalin (TP508) protocol reviewed by a physician in our network.
Start Your ConsultationFind a Pharmacy
Browse PCAB-accredited and FDA 503B-registered compounding pharmacies that supply Chrysalin (TP508).
Pharmacy DirectoryJoin the Association
Access exclusive peptide protocols, provider resources, and community support.
List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.