Dermatology · Investigational
Decorinyl (Tripeptide-10 Citrulline)
No lawful US pathway
01 · Overview
Decorinyl (tripeptide-10 citrulline) is a synthetic tetrapeptide designed to mimic the collagen-binding sites of decorin, a small proteoglycan that regulates how collagen fibrils assemble (PMID 18377618). Rather than increasing decorin production, it is intended to act as a decorin substitute, since functional decorin declines with skin aging (PMID 18377618).
Its development targets collagen quality and organization rather than collagen quantity in aging skin.
02 · Research summary & key findings
In the developer's in vitro collagen fibrillogenesis assays, tripeptide-10 citrulline regulated fibril formation and produced thinner, more uniform collagen fibres, similar to decorin (PMID 18377618). A small randomized controlled study of 24 healthy volunteers reported antiwrinkle effects of tripeptide-10 citrulline alone and with acetyl hexapeptide-3 over 60 days, measured by skin surface analysis (PMID 28150423). Larger independent randomized trials have not been published.
03 · Regulatory status
Decorinyl (Tripeptide-10 Citrulline) is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
No lawful pathway today
Decorinyl (Tripeptide-10 Citrulline) is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so we do not sell it and will not book a consultation for it. That can change: in 2026 FDA began reviewing several peptides for compounding. If you are working on the goal it is studied for, a licensed clinician can tell you what is lawfully available, which may be something else.
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Decorinyl (Tripeptide-10 Citrulline) is an investigational compound, is not FDA-approved, and has no lawful US compounding pathway, so we do not offer it and no clinician we work with will prescribe it. Products sold online as “research chemicals” are not made or tested to the standards required of medicines. If you are working on longevity and healthy ageing, a licensed clinician can tell you at a free consultation whether an FDA-approved or lawfully compounded treatment fits you, or whether nothing does.
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04 · Administration routes
- Topical
References
- [1]A new decorin-like tetrapeptide for optimal organization of collagen fibres Int J Cosmet Sci, 2008. PMID 18377618
- [2]The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study J Cosmet Dermatol, 2017. PMID 28150423
Primary literature
- PubMed: "Decorinyl"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Decorinyl"
Registered interventional and observational studies, including status and phase.
- PubChem: "Decorinyl"
Chemical structure, molecular properties, and bioactivity data.
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