Peptide Association LLC is a for-profit company. We receive compensation from the clinical providers listed on this site. We are not an accrediting body, a licensing board, or a government-affiliated organization. See exactly how we make money.
Cerebrolysin
Overview
A porcine brain-derived peptide preparation consisting of low-molecular-weight neuropeptides and free amino acids that mimic the action of endogenous neurotrophic factors. Cerebrolysin exhibits neurotrophic activity similar to BDNF, GDNF, and CNTF, promoting neuronal survival, synaptic plasticity, and neurogenesis.
Mechanism of Action
It modulates GSK-3beta, CDK5, and calcineurin-NFAT signaling cascades involved in neurodegeneration.
Research Summary & Key Findings
Approved in over 50 countries (not FDA-approved) for stroke, traumatic brain injury, and Alzheimer's disease. A meta-analysis of clinical trials showed modest improvements in global clinical function in Alzheimer's patients (Gauthier et al., Dement Geriatr Cogn Disord, 2015). The CASTA trial in acute ischemic stroke showed improved outcomes at 90 days. Safety concerns regarding prion transmission from porcine brain tissue have been raised but not substantiated.
Clinical Status
Cerebrolysin is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
References
Primary literature
- PubMed: "Cerebrolysin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Cerebrolysin"
Registered interventional and observational studies, including status and phase.
- PubChem: "Cerebrolysin"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
Related Peptides in Cognitive
Semax
InvestigationalA synthetic heptapeptide analog of the ACTH(4-7) fragment (Met-Glu-His-Phe-Pro-Gly-Pro) with nootropic and neuroprotecti...
View detailsSelank
InvestigationalA synthetic analog of the endogenous tetrapeptide tuftsin (Thr-Lys-Pro-Arg) with an added Pro-Gly-Pro sequence for stabi...
View detailsP21 (Peptide)
Research PhaseA small synthetic peptide derived from the active region of ciliary neurotrophic factor (CNTF) designed to promote neuro...
View detailsDihexa
Research PhaseDihexa is a small synthetic hexapeptide derived from angiotensin IV, designed to bind and potentiate hepatocyte growth f...
View detailsNo lawful pathway today
Cerebrolysin is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
Tell me if the status changes
One email, only if this compound's regulatory standing actually moves. Not a newsletter, not a sales sequence.
Join the Association
Access exclusive peptide protocols, provider resources, and community support.
List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.