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MetabolicFDA Approved

Pramlintide (Symlin)

Subcutaneous injection (before meals)
Written by Peptide Association Editorial TeamMedically reviewed by Ian Justl Ellis, MD, CPTLast reviewed Editorial policy

Overview

A synthetic analog of amylin (islet amyloid polypeptide), a 37-amino acid peptide hormone co-secreted with insulin from pancreatic beta cells. Pramlintide has three proline substitutions that prevent amyloid fibril formation while retaining amylin receptor activity.

Mechanism of Action

It slows gastric emptying, suppresses postprandial glucagon secretion, and promotes satiety via area postrema activation, complementing insulin therapy in diabetes management.

Research Summary & Key Findings

FDA-approved in 2005 as adjunct to insulin therapy in type 1 and type 2 diabetes. Clinical trials showed 0.3-0.6% additional HbA1c reduction and 1-2 kg weight loss when added to insulin. Reduces postprandial glucose excursions by 50% through delayed gastric emptying and glucagon suppression.

Clinical Status

FDA Approved

Pramlintide (Symlin) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Administration Routes

Subcutaneous injection (before meals)

References

Primary literature

Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.