Adrenomedullin
Overview
Adrenomedullin is a 52-amino acid peptide hormone produced by vascular endothelial and smooth muscle cells with potent vasodilatory and natriuretic properties. It signals through calcitonin receptor-like receptor complexed with receptor activity-modifying proteins, increasing cyclic AMP to promote vasodilation, angiogenesis, and anti-inflammatory effects.
Mechanism of Action
Adrenomedullin also modulates vascular permeability and exhibits cardioprotective and renoprotective actions.
Research Summary & Key Findings
Plasma adrenomedullin levels correlate with severity and prognosis in heart failure and sepsis, with biomarker studies validating its prognostic utility. Synthetic analogues and stabilized forms are under investigation, though no adrenomedullin-based therapeutic has achieved regulatory approval for cardiovascular indications to date.
Clinical Status
Adrenomedullin is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
References
Primary literature
- PubMed — "Adrenomedullin"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Adrenomedullin"
Registered interventional and observational studies, including status and phase.
- PubChem — "Adrenomedullin"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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