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All peptides

Gastrointestinal · FDA Approved

Secretin

FDA-approved

How to ask your doctor
Written by Peptide Association Editorial TeamLast reviewed Editorial policy

01 · Overview

A 27-amino acid peptide hormone produced by S-cells of the duodenal and jejunal mucosa in response to acid entering the small intestine. Secretin stimulates pancreatic fluid and bicarbonate secretion (PMID 24518494) and stimulates biliary and pancreatic ductal cells to secrete bicarbonate and water, increasing bile volume (PMID 29262229).

It was the first hormone identified, discovered by Bayliss and Starling in 1902 (PMID 11129062).

02 · Research summary & key findings

Synthetic human secretin is used for exocrine pancreatic function testing, diagnosis of gastrinoma, and secretin-enhanced MRCP imaging of the pancreatic ducts (PMID 24518494) (PMID 33263419). In the US, synthetic human secretin (ChiRhoStim) is FDA-approved, while older biologically derived porcine secretin and the synthetic porcine product SecreFlo have been discontinued. A double-blind trial found that a single dose of synthetic human secretin was no better than placebo for autism or pervasive developmental disorder (PMID 10588965).

03 · Regulatory status

Secretin has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.

Secretin is an FDA-approved medicine prescribed for the conditions on its label. It is not part of our intake, so we do not propose protocols for it. If you think it may be relevant to you, talk to your own doctor. How to ask your doctor.

04 · Administration routes

  • Intravenous

References

  1. [1]Lack of benefit of a single dose of synthetic human secretin in the treatment of autism and pervasive developmental disorder N Engl J Med, 1999. PMID 10588965
  2. [2]Secretin, its discovery, and the introduction of the hormone concept Scand J Clin Lab Invest, 2000. PMID 11129062
  3. [3]Secretin: historical perspective and current status Pancreas, 2014. PMID 24518494
  4. [4]Physiology, Bile Secretion , 2022. PMID 29262229
  5. [5]Secretin-Enhanced MRCP: How and Why-AJR Expert Panel Narrative Review AJR Am J Roentgenol, 2021. PMID 33263419

Primary literature

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed. Clinicians: join the network.