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Iseganan (IB-367)
Overview
Iseganan is a 17-amino acid synthetic analog of protegrin, a naturally occurring antimicrobial peptide found in porcine leukocytes. It disrupts microbial cell membranes via a beta-sheet structure stabilized by disulfide bonds, conferring broad-spectrum activity against bacteria, fungi, and some viruses.
Mechanism of Action
Iseganan was developed primarily as an oral rinse to prevent ventilator-associated pneumonia and oral mucositis in immunocompromised patients. Its rapid microbicidal action and low systemic absorption profile supported its formulation for topical oral use.
Research Summary & Key Findings
Phase III trials in ventilator-associated pneumonia prevention did not meet primary endpoints for reducing infection rates, leading to discontinuation of development for that indication. Studies in chemotherapy-induced oral mucositis similarly failed to demonstrate significant clinical benefit. Development was halted in the early 2000s following these trial results.
Clinical Status
Iseganan (IB-367) is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
References
Primary literature
- PubMed: "Iseganan"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Iseganan"
Registered interventional and observational studies, including status and phase.
- PubChem: "Iseganan"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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View detailsNo lawful pathway today
Iseganan (IB-367) is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
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List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.