Urocortin 3
Overview
Urocortin 3, also known as stresscopin, is a 38-amino acid peptide with high selectivity for CRF receptor 2. It produces vasodilation and increases cardiac contractility while exhibiting cardioprotective effects in models of cardiac stress and injury.
Mechanism of Action
The selective CRF2 receptor activation avoids hypothalamic-pituitary-adrenal axis stimulation, potentially offering a favorable profile for cardiovascular therapeutics.
Research Summary & Key Findings
Animal studies have shown that urocortin 3 improves hemodynamics and reduces infarct size in models of myocardial ischemia and heart failure. No clinical trial data in human cardiovascular disease have been published, and the peptide remains in preclinical investigation.
Clinical Status
Urocortin 3 is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
References
Primary literature
- PubMed — "Urocortin 3"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Urocortin 3"
Registered interventional and observational studies, including status and phase.
- PubChem — "Urocortin 3"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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