Bone · FDA Approved
BMP-7 (Osteogenic Protein-1)
FDA-approved
01 · Overview
BMP-7, also known as osteogenic protein-1, is a bone morphogenetic protein with a mature homodimeric structure. Like other BMPs it signals through serine and threonine kinase receptors to activate SMAD transcription factors, promoting differentiation of mesenchymal cells into osteoblasts and chondrocytes.
The recombinant form is delivered on a collagen matrix for localized release. It reached the United States market as a device under a humanitarian device exemption for limited bone-healing indications and was subsequently withdrawn from the United States market by the manufacturer.
02 · Research summary & key findings
In a controlled, prospective, randomized, partially blinded multicenter trial in 122 patients with 124 tibial nonunions treated with intramedullary rodding plus either recombinant human osteogenic protein-1 in a collagen carrier or fresh bone autograft, 81 percent of the osteogenic protein-1 nonunions and 85 percent of the autograft nonunions were clinically successful at 9 months, a nonsignificant difference, with similar results through 2 years (PMID 11314793). Radiographic healing at 9 months was 75 percent with osteogenic protein-1 versus 84 percent with autograft, also not significantly different (PMID 11314793). The product is no longer marketed in the United States.
03 · Regulatory status
BMP-7 (Osteogenic Protein-1) has received FDA approval and is available for clinical use under appropriate medical supervision. Consult a qualified healthcare provider for prescribing information.
BMP-7 (Osteogenic Protein-1) is an FDA-approved medicine prescribed for the conditions on its label. It is not part of our intake, so we do not propose protocols for it. If you think it may be relevant to you, talk to your own doctor. How to ask your doctor.
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BMP-7 (Osteogenic Protein-1) is prescribed for the conditions on its label, and it is not part of our intake. If you are working on injury recovery and tissue repair, a licensed clinician can tell you at a free consultation whether an FDA-approved or lawfully compounded treatment fits you, or whether nothing does.
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04 · Administration routes
- Surgical implantation
References
- [1]Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions J Bone Joint Surg Am, 2001. PMID 11314793
Primary literature
- PubMed: "BMP-7"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "BMP-7"
Registered interventional and observational studies, including status and phase.
- PubChem: "BMP-7"
Chemical structure, molecular properties, and bioactivity data.
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