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Glepaglutide
Overview
Glepaglutide is a long-acting GLP-2 receptor agonist peptide developed for the treatment of short bowel syndrome. GLP-2 promotes intestinal growth, enhances nutrient and fluid absorption, and reduces gastric secretion, thereby improving intestinal function in patients with compromised bowel length.
Mechanism of Action
The compound is administered subcutaneously to sustain therapeutic effects over extended intervals.
Research Summary & Key Findings
Phase 3 trials in adults with short bowel syndrome have demonstrated reductions in the volume of parenteral support required, with results published in gastroenterology journals in 2020 and 2021. The safety profile was generally favorable, with injection-site reactions and gastrointestinal symptoms being most common. Regulatory submissions are under consideration in multiple regions.
Clinical Status
Glepaglutide is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.
Administration Routes
References
Primary literature
- PubMed: "Glepaglutide"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Glepaglutide"
Registered interventional and observational studies, including status and phase.
- PubChem: "Glepaglutide"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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View detailsNo lawful pathway today
Glepaglutide is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
Tell me if the status changes
One email, only if this compound's regulatory standing actually moves. Not a newsletter, not a sales sequence.
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List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.