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Nemifitide
Overview
Nemifitide is a synthetic pentapeptide analog of the endogenous neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH). It acts on melanocortin receptors, particularly MC4, to modulate inflammatory pathways, oxidative stress, and neuronal excitability.
Mechanism of Action
The peptide has been investigated for neuroprotection in settings of acute brain injury and neurodegenerative disease.
Research Summary & Key Findings
A phase II trial in hemorrhagic stroke patients did not demonstrate significant improvement in functional outcomes or mortality. Additional small studies in traumatic brain injury have been conducted, but robust clinical efficacy data remain limited and no regulatory approvals have been obtained.
Clinical Status
Nemifitide is in the investigational stage. While preclinical and early-phase data exist, it has not received regulatory approval for clinical use in the United States.
Administration Routes
References
Primary literature
- PubMed: "Nemifitide"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Nemifitide"
Registered interventional and observational studies, including status and phase.
- PubChem: "Nemifitide"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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View detailsNo lawful pathway today
Nemifitide is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
Tell me if the status changes
One email, only if this compound's regulatory standing actually moves. Not a newsletter, not a sales sequence.
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List Your PracticeDisclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.