Dihexa
Overview
Dihexa is a small synthetic hexapeptide derived from angiotensin IV, designed to bind and potentiate hepatocyte growth factor (HGF) signaling through the c-Met receptor. This action is hypothesized to promote synaptogenesis, dendritic spine formation, and neuronal survival in models of cognitive impairment.
Mechanism of Action
Dihexa exhibits high oral bioavailability and blood-brain barrier penetration due to its small size and lipophilic character.
Research Summary & Key Findings
Preclinical studies in rodent models of Alzheimer disease and traumatic brain injury have demonstrated improvements in spatial learning and memory consolidation. No human clinical trials have been published in peer-reviewed journals, and safety and efficacy data in humans remain absent.
Clinical Status
Dihexa is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
References
Primary literature
- PubMed — "Dihexa"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Dihexa"
Registered interventional and observational studies, including status and phase.
- PubChem — "Dihexa"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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