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LongevityResearch Phase

FOXO4-DRI

Subcutaneous injection, Intravenous
Written by Peptide Association Editorial TeamMedically reviewed by Ian Justl Ellis, MD, CPTLast reviewed Editorial policy

Overview

A D-retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells. In senescent cells, FOXO4 sequesters p53 away from mitochondria, preventing p53-mediated apoptosis and enabling senescent cell survival.

Mechanism of Action

FOXO4-DRI competitively binds p53, releasing it to trigger selective apoptosis of senescent cells while sparing healthy cells, functioning as a senolytic agent.

Research Summary & Key Findings

In vivo studies in naturally aged and fast-aging (XpdTTD/TTD) mice demonstrated restoration of fitness, fur density, and renal function after FOXO4-DRI treatment (Baar et al., Cell, 2017). Selectively induced apoptosis in senescent cells in vitro without affecting proliferating or quiescent cells. Preclinical stage with no human clinical trials initiated. The D-retro-inverso design confers protease resistance for improved in vivo stability.

Clinical Status

Research Phase

FOXO4-DRI is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.

Administration Routes

Subcutaneous injectionIntravenous

References

Primary literature

Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.