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GHRP-1
Overview
Growth Hormone Releasing Peptide-1 is a synthetic hexapeptide belonging to the growth hormone secretagogue family. It acts as a weak agonist at the ghrelin receptor (GHS-R1a) to stimulate pulsatile growth hormone release from the anterior pituitary.
Mechanism of Action
GHRP-1 has limited potency compared to later-generation secretagogues and served primarily as a prototype for subsequent drug development.
Research Summary & Key Findings
Early pharmacological studies in healthy volunteers demonstrated modest growth hormone release with reduced potency relative to GHRP-2 and GHRP-6. The compound has not advanced to pivotal clinical trials due to its limited efficacy and the availability of more potent analogs. It remains a research tool for studying growth hormone secretion pathways.
Clinical Status
GHRP-1 is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
References
Primary literature
- PubMed: "GHRP-1"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "GHRP-1"
Registered interventional and observational studies, including status and phase.
- PubChem: "GHRP-1"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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CJC-1295
In Clinical TrialsA synthetic analog of growth hormone-releasing hormone (GHRH) with a Drug Affinity Complex (DAC) that binds to albumin, ...
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In Clinical TrialsA highly selective growth hormone secretagogue that acts on ghrelin/GHS receptors in the pituitary gland to stimulate GH...
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FDA ApprovedA synthetic 29-amino acid analog of GHRH representing the shortest fully functional fragment of the native 44-amino acid...
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FDA ApprovedA synthetic GHRH analog consisting of the 44-amino acid sequence of human GHRH with a trans-3-hexenoic acid modification...
View detailsNo lawful pathway today
GHRP-1 is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so there is nothing for us to sell you here and no consultation to book. That can change: eight peptides moved back to a lawful pathway in February 2026.
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