Ularitide (Urodilatin)
Overview
Ularitide is a synthetic 32-amino acid peptide analogue of urodilatin, a natriuretic peptide produced in renal tubular cells. It binds to guanylyl cyclase A receptors to increase cyclic GMP, resulting in vasodilation, enhanced sodium excretion, and suppression of the renin-angiotensin-aldosterone system.
Mechanism of Action
The peptide was developed for treatment of acute decompensated heart failure with the goal of improving renal function and hemodynamics.
Research Summary & Key Findings
The TRUE-AHF trial (European Heart Journal, 2017) evaluated ularitide in over 2,000 patients with acute heart failure but did not meet its primary endpoint of cardiovascular mortality reduction. Despite promising earlier phase 2 data showing hemodynamic benefits, regulatory approval was not pursued following the neutral phase 3 results.
Clinical Status
Ularitide (Urodilatin) is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.
Administration Routes
References
Primary literature
- PubMed — "Ularitide"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Ularitide"
Registered interventional and observational studies, including status and phase.
- PubChem — "Ularitide"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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