RecoveryIn Clinical Trials

TB-500 (Thymosin Beta-4)

Name: TB-500 (Thymosin Beta-4) — Mechanism, Dosing & Research
Creator: Peptide Association Editorial Team

Subcutaneous injection

Written by Peptide Association Editorial TeamMedically reviewed by Ian Justl Ellis, MD, CPTLast reviewed August 3, 2026Editorial policy

Overview

Thymosin Beta-4 is a 43-amino acid actin-sequestering protein involved in cell migration, differentiation, and tissue repair. It promotes wound healing by upregulating cell-building proteins such as actin and laminin, facilitating cell migration to sites of injury.

Mechanism of Action

TB-500 also has anti-inflammatory properties mediated through NF-kB pathway modulation.

Research Summary & Key Findings

Accelerated dermal wound repair and corneal epithelial healing in clinical studies. Phase II trials showed improved cardiac function post-myocardial infarction (RegeneRx Biopharmaceuticals).

Clinical Status

In Clinical Trials

TB-500 (Thymosin Beta-4) is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.

Administration Routes

Subcutaneous injection

References

Primary literature

PubMed — "TB-500"
Peer-reviewed literature indexed by the National Library of Medicine.
ClinicalTrials.gov — "TB-500"
Registered interventional and observational studies, including status and phase.
PubChem — "TB-500"
Chemical structure, molecular properties, and bioactivity data.

Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.