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Ecnoglutide

Subcutaneous injection
Written by Peptide Association Editorial TeamMedically reviewed by Ian Justl Ellis, MD, CPTLast reviewed Editorial policy

Overview

Ecnoglutide is a long-acting GLP-1 receptor agonist peptide designed for once-weekly subcutaneous administration. It acts by enhancing glucose-dependent insulin secretion, reducing glucagon levels, and delaying gastric emptying to improve glycemic control and promote weight loss.

Mechanism of Action

The extended half-life is achieved through structural modifications that resist enzymatic degradation and renal clearance.

Research Summary & Key Findings

Phase 2 trials in adults with type 2 diabetes have demonstrated reductions in HbA1c and body weight consistent with the GLP-1 agonist class. Safety data showed a typical profile of gastrointestinal adverse events. Further development is needed to establish positioning relative to existing long-acting GLP-1 therapies.

Clinical Status

In Clinical Trials

Ecnoglutide is currently undergoing clinical trials. It is not yet FDA-approved and is available only through clinical research settings or investigational protocols.

Administration Routes

Subcutaneous injection

References

Primary literature

Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.

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Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed.