Dermatology · Research Phase
Eyeseryl (Acetyl Tetrapeptide-5)
No lawful US pathway
01 · Overview
Acetyl Tetrapeptide-5 is a synthetic tetrapeptide modified with an acetyl group to improve stability. It is marketed to reduce under-eye puffiness and fluid accumulation, with suppliers proposing effects on capillary permeability and on angiotensin-converting enzyme (ACE) activity.
These mechanisms are based mainly on supplier data, with very little independent peer-reviewed confirmation.
02 · Research summary & key findings
The only independent study found tested acetyl tetrapeptide-5 in cultured human skin fibroblasts, where it was included at a concentration chosen for its effect on angiotensin-converting enzyme 1 activity and combined with other peptides in a mixture that reduced oxidative stress markers (PMID 33849044); the endothelial permeability and interleukin-1 effects described by suppliers have not been published. Manufacturer-reported clinical improvement in under-eye puffiness has not appeared in indexed peer-reviewed journals, and no controlled human trials are available.
03 · Regulatory status
Eyeseryl (Acetyl Tetrapeptide-5) is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
No lawful pathway today
Eyeseryl (Acetyl Tetrapeptide-5) is not FDA-approved and does not currently have a lawful prescription or compounding pathway in the United States, so we do not sell it and will not book a consultation for it. That can change: in 2026 FDA began reviewing several peptides for compounding. If you are working on the goal it is studied for, a licensed clinician can tell you what is lawfully available, which may be something else.
See the 1 FDA-approved compound in Dermatology
Tell me if the status changes
One email, only if this compound's regulatory standing actually moves. Not a newsletter, not a sales sequence.
Looking for a lawful, clinician-prescribed option for longevity and healthy ageing?
Eyeseryl (Acetyl Tetrapeptide-5) is a research compound, is not FDA-approved, and has no lawful US compounding pathway, so we do not offer it and no clinician we work with will prescribe it. Products sold online as “research chemicals” are not made or tested to the standards required of medicines. If you are working on longevity and healthy ageing, a licensed clinician can tell you at a free consultation whether an FDA-approved or lawfully compounded treatment fits you, or whether nothing does.
Explore lawful options (free intake)About 3 minutes. If a protocol is prescribed through our provider, we earn 10% of the sale. See the receipts.
04 · Administration routes
- Topical
References
- [1]Protective and Anti-Aging Effects of 5 Cosmeceutical Peptide Mixtures on Hydrogen Peroxide-Induced Premature Senescence in Human Skin Fibroblasts Skin Pharmacol Physiol, 2021. PMID 33849044
Primary literature
- PubMed: "Eyeseryl"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov: "Eyeseryl"
Registered interventional and observational studies, including status and phase.
- PubChem: "Eyeseryl"
Chemical structure, molecular properties, and bioactivity data.
Related peptides in Dermatology
Disclaimer: This information is provided for educational and research purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any peptide therapy. The Peptide Association does not endorse or recommend any specific treatment protocol. See our editorial policy for how this content is produced and reviewed. Clinicians: join the network.