Eyeseryl (Acetyl Tetrapeptide-5)
Overview
Acetyl Tetrapeptide-5 is a synthetic tetrapeptide modified with an acetyl group to improve stability and cellular uptake. The peptide is proposed to reduce periorbital edema by modulating capillary permeability and enhancing lymphatic drainage, potentially through downregulation of pro-inflammatory cytokines such as interleukin-1.
Mechanism of Action
Its application is focused on reduction of under-eye puffiness and fluid accumulation.
Research Summary & Key Findings
In vitro studies on endothelial cell monolayers have demonstrated reduced permeability and decreased inflammatory marker expression. A small clinical trial reported subjective improvement in periorbital edema after four weeks, though the study lacked control groups and has not been reproduced in major peer-reviewed dermatology journals.
Clinical Status
Eyeseryl (Acetyl Tetrapeptide-5) is in the research phase with limited clinical data in humans. Current evidence is primarily derived from preclinical (animal or in vitro) studies.
Administration Routes
References
Primary literature
- PubMed — "Eyeseryl"
Peer-reviewed literature indexed by the National Library of Medicine.
- ClinicalTrials.gov — "Eyeseryl"
Registered interventional and observational studies, including status and phase.
- PubChem — "Eyeseryl"
Chemical structure, molecular properties, and bioactivity data.
Study-level citations for this compound are being verified against the primary sources before publication. The database queries above return the current indexed literature in the meantime.
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